1、Sustainability and Single-Use Systems:From Vision to ActionMagali Barbaroux,Sustainability Committee ChairVachette,Elisabeth-SartoriusNarendar,Yeshwanth Saint GobainMitchel,Matt-AvientECI SUT VI Single-Use Technologies:Established,Emergent,Agile,Sustainable?Conference Chairs Magali Barbaroux(Sartori

2、us)Sheryl Kane(Takeda)Seongkyu Yoon(U-Mass Lowell)2023 Sept.10-13Boston MAHyatt Regency HotelREGISTRATION IS OPENhttps:/engconf.us/conferences/biotechnology/single-use-technologies-vi/BPSA Sustainability(technical)CommitteeMission Provide members information on how SUT support biomanufacturing call

3、for sustainability&takes actions to prove BPSA seriously tackle sustainability concerns.Allow members to be informed on environmental sustainability tools and trends in the biomanufacturing and polymer industry,to share ideas and good practices.Members Approx.42 active members(attended at least one

4、monthly meeting)(33 in 2022)Average of 20 attendees|meeting(18 in 2022)INFORMSHAREACTAttendance 20230510152025JANFEBMARAPRMAYJUNBoard Sponsor:Brian Chung,Solvay|Committee chair:Magali Barbaroux,SartoriusObjectivesCreate and clearly state an industry message inside and outside linked to SDGs goals Mo

5、nthly opening sustainability spotlights1-2 webinarsINFORM,SHARE&ACTPublications,E-book,glossary,LinkedInThank you Baillie,Megan-Barrentine,Robert-Bogen,Jon-Calmels,Caroline-Chen,Joy-Chung,Brian-Clark,Chris-Cook,Hubert-Collins,Francois-Cormier,Bryce-Cousin,Olivier-Daumke,Ralph-Ettie,Derek-Flanagan,Sh

6、annon-Grube,Kallee-Hanson,Colin-Heiler,Dianne-Horowski,Brian-Horst,Kendall-Jarmey-Swan,Claire-Jermyn,Christian-Kamph,Evan-Kuyl,Pierre-Love,Calum-Mariner,Amanda-McCool,Jeanette-Miles,Merete-Mitchell,Matt-Narayanan,Ravi-Narendar,Yeshwant-Ouellette,Matthew-Petrich,Mark-Roalandt,Elke-Shih,Cherry-Snyder,

7、Mitchell-Springael,Sabine-Strohben,Bill-Tan,Chor Sing-Vachette,Elisabeth-Young,DonActive contributors:Avient,Burkert,Corning,Cytiva,Daikin,DPS,DuPont,Entegris,GSK,GEA,Gore,High Purity England,ILC Dover,KrystalBio,NewAge,Nordson Medical,Meissner,Pfizer,PendoTECH,Qosina,Repligen,RubiusTherapeutics,Sai

8、nt-Gobain,Sartorius,Sealed Air,Solvay,ThermoFisher,Watson Marlon,WoodSustainability and Single-Use Systems:From Vision to ActionContent:Context and ideality Case studies,illustrations Q&AThe UNs sustainable development goals context Triple bottom line:People Planet Profit 17 Interconnected goals Cor

9、porate ChallengeIdentify THE driving goalAs we can,contribute to others Activities must be transparentCant be achieved alonePharma driving goalCollaboration imperativeReasons for Industry Adoption of SU Technologies Improved consistency in manufacturing processes Flexibility to design a purpose-buil

10、t facility and the ability to amend SU technologies as needed Fast process deployment and changeover Less initial investment in fixed equipment enabling significant cost-savings Reduced water use due to the elimination of steaming and cleaning procedures Smaller facility footprint reduces the requir

11、ement for HVAC,the most significant factor for energy usage in the facilityBiotech industry environmental landscapeEuropean Federation of Pharmaceutical Industries and association PIE=pharmaceutical in environment-https:/www.efpia.eu/about-medicines/development-of-medicines/regulations-safety-supply

12、/environment-health-safety-and-sustainability/A 2019 study found that the climate footprint of healthcare was representing 4.4%of total global emissions(1)Total amount of carbon emitted|year by public companies in the biotech and pharma industry is more than the semiconductor or forestry and paper i

13、ndustry sector.(2)Fast-growing global biotech and pharma industry=significant contributor to climate change but beginning to move in the right direction,with some of the largest companies demonstrating leadership on emissions reductions(3)(1)https:/noharm-global.org/sites/default/files/documents-fil

14、es/5961/HealthCaresClimateFootprint_090619.pdf(2)https:/www.mygreenlab.org/blog-beaker/my-green-lab-measures-carbon-impact-of-biotech-and-pharma(3)The Carbon Impact of Biotech&Pharma,October 2022(mygreenlab.org)Toward Carbon NeutralityFor most industries biotech and pharma is no exception scope 3 em

15、issions are significantly larger than scope 1 and 2 combined.To understand the true carbon impact of an industry,critical to evaluate the entire carbon footprint,including scope 3 emissions in the upstream and downstream value chainToward(Plastic)CircularityEnd of lifePlastic usageUSESourcing12Recyc

16、ling plasticMinimize amount of plastic(products and packaging)-efficiencyDecouple plastic from fossil feedstockClimate changePlastic pollution(1)Derived from Carbone 4 slide consulting firm for low carbon stategiesReferences*1.Aseptic Virtual conference,March 2021,Upstream Cell-based Vaccine Product

17、ion:Improving the Environmental Footprint,Whitford,Barbaroux2.World Economic Forum 2016 The New plastic Economy3.UNEP SINGLE-USE PLASTICS-A Roadmap for Sustainability4.Medical plastic market is estimated to 7.7 million tons in 2020( a global market of 400 million de tons,e.g.1,9%.5.Health-care waste

18、(who.int) Impacts of Single-Use Systems.”Single-Use Technology in Biopharmaceutical Manufacture,2nd Edition,edited by Regine Eibl and Dieter Eibl,John Wiley&Sons,2019,271-285.9.J.Ignacio,From Single-Use to Re-Use in the MedecineMaker,June 201810.BPSA“The Green Imperative”series-BioProcess Intl 2020

19、and 202111.W.Flanagan,Single-use and sustainability:quantifying the environmental impact,BioProcess Online,2016.12.European Commission:A circular economy for plastics,Insights from research and innovation to inform policy&funding decisions13.K.Budzinski,et al.,“Introduction of a process mass intensi

20、ty metric for biologics,”New BIOTECHNOLOGY 49(2019)37-42.14.Kristi Budzinski et al.Streamlined life cycle assessment of single use technologies in biopharmaceutical manufacture.New Biotechnology,2022.15.Luu,D and al,Recycling of Post-Use Bioprocessing Plastic ContainersMechanical Recycling Technical

21、 Feasibility.Sustainability(Switzerland)202316.Sartorius-Driving Environmental Sustainability in the Biopharmaceutical Industry White Paper Environment|Sartorius*Last access to web sites July 7th 2023Examples of circularity initiativesElisabeth Vachette14Initiatives to improve packagingEva Schfers p

22、resents the old(left)and new packaging(right).Same Safety,Less Waste:new Packaging For MaxiCaps Sterile FiltersSmaller,lighter,and recyclable with no compromise on quality more complicated that what it looks!15(1)Figure taken from:Vachette,Elisabeth&Fenge,Christel&Cappia,Jean Marc&Delaunay,Lucie&Gre

23、ller,Gerhard&Barbaroux,Magali.(2014).Robust and convenient single-use processing:The superior strength and flexibility of flexsafe bags.(2)Plastics-the Facts 2022 Plastics EuropeInitiatives to improve waste management(Aubagne)Increased waste recycling Improved waste collection and sortingReduced fil

24、m consumptionEnhanced film recyclability(1)Sorting is a critical success factor for recycled polymer value,especially for color“Plastics packaging waste recycling rates are 80 x higher(and plastics waste 13x higher)when collected separately compared to mixed waste(2)Working group:Sanofi,Sartorius an

25、d Veolia.Objective:Challenge widespread thought that SUTs cannot be recycled in standard waste streams for plastics(1)and collaboratively answer the following questions:Is there any application where post used bags are not considered bio-hazardous?How to technically recycle a SUT bag,composed of a m

26、echanically recyclable film(2)(sorting strategy)?What will be the quality of the recycled content(3)?What impact on environmental profiles of SUT end of life?Identified opportunity:bioprocessing bags used for media and buffer preparation and storageStill represent the largest amount today.Most buffe

27、rs and media are not hazardous fluids.Flexsafe Bag chamber designed to be recyclable|biggest weight contributor in simple bags.Materials for the constitution are well known and characterized.16(1)most frequent objections:mixed plastic,multilayer films,bio-hazardous post-use products,recycling has a

28、higher footprint than waste to energy.)(2)Recommended recycling option in the recycling hierarchy(3)Laboratory scale on representativeCollaboration in recycling post use non biohazardous filmOrder of magnitude“Simple”bag mass distribution(measured)Bag chamber 43,7%Plastic packaging 14,1%Carboard pac

29、kaging 31,9%Connectors&tubes 10,3%17Methodological approachQuantitative physical|mechanical tests and analysis(FTIR,DSC,TGA,density,MFI,color,tensile,flexural,and Charpy choc)Results show that recycled PE can go to applications with similar performance requirements than the one of virgin material(fi

30、lms,bags,pipes and fittings,profiles,and flexible sheets)Confirmed that sorting is a critical success factor for recycled polymer value,(color doesnt impact mechanical properties,but negative impact on value)Post-useManual dismantlingCuttingShear Crushing#1Shear Crushing#2GrindingExtrusionInjection

31、MoldingOn the left,cable ties mixed.18(1)Data assumptions available for upload:https:/ Environmental Profiles of Different End of Life ScenariosComparative LCA(1)(theoretical framework),shows mechanical recycling for end of life presents the advantage of keeping material in the loop without a signif

32、icant statistical difference compared to incineration with regards to the climate change indicator.Recycled Flexsafe bag chambers could technically be used for films,bags,pipes and fittings,profiles,and flexible sheets provided an appropriate sorting and massification solution is identified.The comp

33、arative LCA,based on a theoretical framework,shows that mechanical recycling for end of life presents the advantage of keeping material in the loop without a significant statistical difference compared to incineration with regards to the climate change indicator.Several challenges remainTrade-off be

34、tween the quality and quantity of the recycled plastic needs to be further evaluated.Cost and efficiency of sorting is another area that needs to be addressed.Lack of accurate data(e.g.,production volume,energy consumption,quantities of emissions)related to the emergence of this new circular scheme

35、product limits the value of the LCA*Published in open-source Sustainability 2022,14,1555719*A whole environmental impact assessment,with different logistic scenarios to ensure the economic viability from a cost perspective,would require a more detailed cradle-to-cradle LCA,with more accurate data(ra

36、w materials,SUA production,location use,waste treatment streams),with relevant stakeholders,when the recycling scheme at scale will be defined.ConclusionTOGETHER,WE CREATE A BETTER LIFECIRCULARITY AT SAINT-GOBAINCase study from Ceramics used in Glass ProductionYeshwanth NarendarVice-President R&D an

37、d InnovationSaint-Gobain Life Sciences21|321HIGH PERFORMANCE SOLUTIONS4The Saint-Gobain GroupCONSTRUCTIONINDUSTRYCONSTRUCTION CHEMICALSSURFACE SOLUTIONSABRASIVES COMPOSITE SYSTEMSADHESIVES AND SEALANTSEurope,Middle-East,AfricaNorth AmericaLatin AmericaAsia-PacificIndiaTape SolutionsComposite Solutio

38、nsThin FilmsCERAMICSMOBILITYVETROTEXINDUSTRIAL FABRICS EUROPECONSTRUCTION PRODUCTSEUROPECONSTRUCTION INDUSTRYAMERICASCEMENTCONCRETEPrecastReady-mix concreteDecorative ConcreteScreedGypsumSEKURIT ORIGINAL EQUIPMENT MANUFACTURER(OEM)AUTOMOTIVE GLASSREPLACEMENTSEKURIT TRANSPORTAEROSPACEGLASS REFRACTORI

39、ESZIRCONIAPERFORMANCE CERAMICSAND REFRACTORIESQUARTZCATALYST SUPPORTSSPECIALTY POWDERSVALOREF-RECYCLINGENGINEERED COMPONENTSBearingsJoints Automobile Polymer SolutionsOmniseal SolutionsSPECIALTY BUILDING MATERIALSMaterials based solutions across our marketsLIFE SCIENCESBIOPROCESS SOLUTIONSMEDICAL CO

40、MPONENTSINDUSTRIAL AND CONSUMER SOLUTIONSELECTRONICSReference-33%CO2(Scopes 1&2)-16%CO2(Scope 3)-30%new raw material-80%waste reductionCarbon neutrality20502030201722 Saint-Gobain ObjectivesCircular economy Inorganic MaterialsSaint-Gobain ceramiccompaniesShaped productsGlass Refractory blocksAbrasiv

41、esIndustriesGlass,abrasives.ManufacturingNew+Recycled raw materialsSaleRecyclingCollectWasteScope 1:Company Direct Emissions(e.g.energy&plant process)Scope 2:Company Indirect Emissions(e.g.electricity for power used in plants)Scope 3:Indirect value chain emissions(e.g.raw materials,transport,use,end

42、-of-life23 Punctual waste collection Furnace demolition operation Dedicated team on-site Regular waste collection3 SERVICESGlass Furnaces-Building flat glass-Automotive glass-Containers(incl.Pharma)-Glass wool&fibers(insulation)1000s of tons of ceramics usedFurnace Life span of 10-20 years“Valoref s

43、tarted to recycle ceramics used for glass furnaces:Production waste to post use”241.Industrial use2.Waste collection3.Waste sortingSorting line operators4.Crushing5.ResaleRevalorization 85%6 PRODUCT RANGESSorting:-the material type-level of contamination20,000 tonsPer year87%Recycled in 202125 100%o

44、f recyclingPatentedInsulation fiber furnaceNew refractory blocksCrIII-based slurryContamination with CrVIWaste treatment26Engineered Products“fused”/connected together in a glass furnace-Separate product into raw materials to enable recyclingContamination is a common issue-Develop economical deconta

45、mination process to enable recyclingGlass furnace ceramics need to work for 15+years-Some recycled raw materials are used for less demanding applicationsTesting feasibility of single use plastics recycling-leveraging Saint-Gobains presence in Life Science,Industrial and ConstructionPRODUCT CARBON FO

46、OTPRINTCopyright 2023,Avient Corporation.All Rights Reserved.A carbon footprint describes the total climate change impact greenhouse gas(GHG)emissions that a product,action,or person has.WHAT IS CARBON FOOTPRINT?28Avient CorporationCARBON EMISSIONS DATA CO2 emissions have increased by about 90%over

47、the past 50 years21740+companies set net zero commitments370%of countries have net zero targets32500companies have set emission reduction targets3Source 2:https:/www.epa.gov/ghgemissions/global-greenhouse-gas-emissions-dataSource 3.https:/sciencebasedtargets.org/companies-taking-actionAvient Corpora

48、tion29UNDERSTANDING PRODUCT CARBON FOOTPRINTAvient Corporation30Follows ISO 14067:2018 Carbon Footprint of Products Specifies principles and guidelines for the quantification and reporting of the carbon footprint of a productThird-Party Certified by TUV Certificate confirms that a product meets defi

49、ned criteria and defined safety-relevant aspectsMETHODOLOGYAvient Corporation31IMPACT OF RAW MATERIALT R A D I T I O N A LP AV S.R E C Y C L E DP AAvient Corporation321.01PAREC PA10.0990%0.090.099.91Traditional PAScope 1Scope 2Scope 310.09kg CO2e/kg product0.090.090.83Recycled PAScope 1Scope 2Scope

50、31.01kg CO2e/kg productIMPACT OF RAW MATERIALT R A D I T I O N A LP AV S.B I OP AAvient Corporation333.82PABIO PA9.7260%0.090.099.54Traditional PAScope 1Scope 2Scope 39.72kg CO2e/kg product0.090.093.64Bio PAScope 1Scope 2Scope 33.82kg CO2e/kg productSUSTAINABLE SOLUTIONSI N D U S T R Y-F I R S T N E U T R A L P C F T P E SAvient Corporation34-1012345reSound Ultra-Low CarbonFootprintStandard TPEkg CO2 equivalent/kg productreSound Ultra-Low Carbon Footprint TPEsComparable performanceGlobally available