1、Fby(Title page design to come)2023 State of the Industry ReportCultivated meat andseafoodAbout GFIThe Good Food Institute is a nonprofit think tank working to make the global food system better for the planet,people,and animals.Alongside scientists,businesses,and policymakers,GFIs teams focus on mak

2、ingplant-based and cultivated meat delicious,affordable,and accessible.Powered by philanthropy,GFI is aninternational network of organizations advancing alternative proteins as an essential solution needed to meet theworlds climate,global health,food security,and biodiversity goals.To learn more,ple

3、ase visit gfi.org.Fuel the future of food at gfi.org/donateJoin GFIs email lists at gfi.org/newslettersTable of contentsEditors note.3Executive summary.7Commercial landscape.7Investments.9Science and technology.10Government and regulation.10Commercial landscape.12Facilities.15Involvement by diversif

4、ied companies.17Partnerships.19Product launches.21Industry associations.21Consumer insights.23Nomenclature and messaging appeal.23Consumer awareness,familiarity,and understanding.24Consumer willingness to try.26Consumer research and demographic insights around the world.29Investments.34Liquidity eve

5、nts.41Other financing.41Science and technology.43Research across the sector.43Scientific ecosystem.51Resources for scientists.53Government and regulation.56Global public funding.56Regulation by country.58Global cooperation and coordination.64Outlook.672024 outlook.67Long-term outlook.68External proj

6、ections.69Acknowledgements.762023 State of the Industry Report/Cultivated meat and seafood1Editors noteIn the history of food and agriculture,2023 was amilestone yearthe year that real animal meat madewithout animals was first approved for sale in theworlds largest economy.For the first time,U.S.con

7、sumers ordered cultivated meat at tworestaurants helmed by world-renowned chefs.Additionally,cultivated meat broadened into newsettings in Singapore,including the first butcherywhere it was on display and served in the adjoiningbistro.And just after 2023 ended,there was moreexciting news for cultiva

8、ted meat:in January 2024Israel became the third country to advance theapproval of cultivated meat sales,and the first toadvance the approval of cultivated beef.Yet the year was not without its challenges.Fundingconstraints,difficulties with scaling,and the spreadof misinformation and disinformation

9、all posedobstacles for cultivated meat.Consumer education,understanding,and adoption are still in the earlystages.And the work to secure increasedgovernment and private investment continues.Despite these headwinds,the stark realities of ourfood system remain:Global meat consumption isprojected to ri

10、se significantly by 2050,and animalagriculture alone accounts for between 11 and 20percent of greenhouse gas emissions.Takentogether,these projections point to the urgent needfor the kinds of solutions provided by alternativeproteins.If the world is to achieve our climate,biodiversity,public health,

11、and food security goals,reimagining theway meat is made will be as essential as the globaltransition to renewable energy.When compared toconventional meat,alternative proteins reduceemissions,feed more people with fewer resources,reduce pandemic and antibiotic-resistance risks,andfree up lands and w

12、aters around the world forrestoration and recovery.GFIs annual State of the Industry reports equip foodsystem stakeholders with an in-depth understandingof the alternative protein market and its challengesand opportunities.These reports also serve as aglobal call to action:Alternative proteins are a

13、griculturalinnovations that,with proper levelsof government and private support,will help ensure planetary and publichealth,transforming our global foodsystem for the better.Cultivated meat is a powerful tool for tackling suchchallenges.It can provide the sensory and nutritionalvalues meat consumers

14、 crave without the downsidesof conventional animal agriculture.At scale,cultivated meat could enable a shift toward lessresource-intensive ways of producing protein.Butfirst,the industry must overcome challenges likedisinformation and proposed bans or restrictions oncultivated meat,in the United Sta

15、tes and around theworld.Despite these obstacles,the next generationof consumers are signaling enthusiasm for cultivatedmeat as a solution to eating meat made with fewerresources and less harm to the environment.This report details the innovations and developmentsthat moved the field of cultivated me

16、at forward in2023.But there is still much to be done.2023 State of the Industry Report/Cultivated meat and seafood2As a nonprofit and international network oforganizations,GFI is accelerating alternative proteininnovation and bringing more people into the field.Policymakers and governments,scientist

17、s andstudents,industry leaders and global citizens can allensure that the sector of nature-positive proteinscontinues to progress,offering the world a far moresustainable food future.With gratitude and deep respect to all those on thisjourney,we invite you to dig deep into this 2023State of the Indu

18、stry report.Best,Caroline BushnellSVP of Corporate EngagementLiz Specht,PhDSVP of Science and TechnologyJessica AlmySVP of Policy andGovernment RelationsAbout GFIs State of the Industry Report seriesGFIs State of the Industry Report series serves as our annual alternative protein sector deep-dive.Th

19、eseries compiles business developments,key technologies,policy updates,and scientific breakthroughsfrom around the world that are advancing the entire field.This years reports include:Cultivated meat and seafoodPlant-based meat,seafood,eggs,and dairyFermentation:Meat,seafood,eggs,and dairyGlobal pol

20、icy:Public support,regulation,and labelingThe Cultivated meat and seafood report synthesizes 2023 updates in the global cultivated meatindustrythe industry dedicated to making real meat and seafood by growing animal cells.Animal cellculture technology has promising applications beyond meat productio

21、n,including dairy,eggs,gelatin,drugs and supplements,and materials.This report focuses on cultivated meat and seafood.For a primeron the process of creating cultivated meat,please visit GFIs science of cultivated meat page.Symbols to look forThroughout the 2023 State of the Industry Report series,lo

22、ok for symbols highlighting how developments in thepast year advanced the alternative protein sector in the areas of health and nutrition,sustainability,andpath-to-market progress.Dig deeper and Opportunity icons are calls to action for researchers,investors,andothers seeking to learn more and advan

23、ce the field.HealthSustainabilityOpportunityPath-to-marketDig deeperPlease note that The Good Food Institute is not a licensed investment or financial advisor,and nothing in this report is intended or should be construed as investment advice.2023 State of the Industry Report/Cultivated meat and seaf

24、ood3About the Good Food InstituteAs a nonprofit think tank and international network of organizations powered by philanthropy,GFI works alongsidescientists,businesses,and policymakers to make alternative proteins as delicious,affordable,and accessible asconventional meat.In Asia Pacific,Brazil,Europ

25、e,India,Israel,and the United States,our teams are mobilizingthe international community to use markets and technology to replace harmful practices with ones that are betterfor the climate and biodiversity,food security,and global health.We focus on three programmatic priorities:1.Cultivating a stro

26、ng scientific ecosystemGFIs science and technology teams map out the most neglected areas that will allow alternative proteins tcompete on taste and price.We produce open-access analyses and resources,educate and connect the negeneration of scientists and entrepreneurs,and fund research that benefit

27、s alternative protein developmenacross the sector.2.Influencing policy and securing government investmentGFIs policy teams ensure that alternative proteins are a part of the policy discussion around climate changmitigation and global health.In every region where we have a presence,we advocate for go

28、vernmentinvestment in alternative proteins and educate regulators on novel proteins such as cultivated meat.3.Supporting industry to advance alternative proteinsGFIs corporate teams are replicating past market transformations and partnering with companies andinvestors across the globe to drive inves

29、tment,accelerate innovation,and scale the supply chainall fasterthan market forces alone would allow.Stay connectedNewsletters|GFIs suite of expertly curated newsletters puts timely news,insights,and opportunities rightin your inbox.Check out gfi.org/newsletters to find the ones most suitable for yo

30、ur interests.Monthly seminar series|Each month,we host online seminars with leading experts from around the world:The Business of Alt Protein series is geared toward a commercially focused audience on topics related tostarting and scaling a good food business.The Science of Alt Protein series addres

31、ses a technical audienceand focuses on cutting-edge research developments that enable alternative protein innovation.This State of the Industry Report series,as well as all of GFIs open-access insights and data,are made possible bygifts and grants from our global community of donors.If you are inter

32、ested in learning more about giving to GFI,please visit here or contact philanthropygfi.org.2023 State of the Industry Report/Cultivated meat and seafood4Executive summaryExecutive summaryIn 2023,cultivated meat arrived in U.S.restaurantsfor the very first time.The year also deliveredadvances in cul

33、tivated meat across science,innovation,talent,and public and private sectorsupport.Yet this still-early-stage industry facedobstacles in 2023,including distorted mediacoverage questioning the technology.Despiteheadwinds,cultivated meat has the potential totransform protein production.More than 170 c

34、ultivated meat companies and arapidly growing number of scientists are hard at workinnovating and optimizing cultivated meat productsso consumers can enjoy the foods they love withoutsacrifice.For the first time ever,U.S.restaurantsserved cultivated chicken,brought to Americansplates by two world-re

35、nowned chefs.Freshconsumer insights and market analysis pointed togrowing international interest in cultivated meat.New partnerships and global alliances formed toadvance the science and scaling of cultivated meat.In a challenging private funding environment,cultivated meat and seafood companies sti

36、ll raised$225.9 million in 2023.And with the January 2024milestone of Israel advancing the approval ofcultivated beef,the industry took another significantleap forward in reimagining how meat is made.Cultivated meat and seafood,part of our 2023 Stateof the Industry Report series,takes a field-wide v

37、iewof the progress made over the past year.Commercial landscapeMajor path-to-market milestonesIn the United States,cultivated chicken productsfrom UPSIDE Foods and GOOD Meat debuted attwo restaurants.The June approval of cultivated meat for sale inthe United States sparked major media coveragein out

38、lets like The New York Times,NPR,TIME,CBS Sunday Morning,and more.Hubers Butchery in Singapore became theworlds first butchery to sell cultivated meatwhen it began carrying GOOD Meats cultivatedchicken in its bistro.In January 2024,Israel became the thirdcountry in the world to advance the approval

39、ofcultivated meat(Aleph Farms cultivated beefproduct)and the first country to advance theapproval of cultivated beef.Company landscapeAround the world,the number of publiclyannounced cultivated meat companies(focusedprimarily on cultivated meat inputs or endproducts)rose to 174 in 2023,up from 166 i

40、n2022.An increasing number of companies arefocusing on the cultivated meat value chainbeyond end-product manufacturing.At least50 companies identify bioprocess design,cellline development,and cell culture media asfocus areas.Large food company involvementADM partnered with Believer Meats to refinean

41、d expand the cultivated meat productionprocess.Large company involvement in cultivated meatdeepened,and Danone and Central BottlingCo.which owns Coca-Cola Israelbothinvested in cultivated milk.2023 State of the Industry Report/Cultivated meat and seafood6Power of partnershipsJBS partnered with the F

42、ederal University ofSanta Catarina on cultivated meat research anddevelopment.Aleph Farms partnered with chef MarcusSamuelsson to serve the companys Aleph Cutssteaks in the United States once they receiveregulatory approval.This follows the trends ofother cultivated meat companies,like UPSIDEFoods a

43、nd GOOD Meat,partnering with chefs tobring their products to the U.S.market.Infrastructure momentumIn 2023,10 new cultivated meat facilitiesopened across Asia,Australia,Europe,NorthAmerica,and the Middle East.Two large-scaleplantsMosa Meats 30,000-square-foot facilityin the Netherlands and CellXs fa

44、ctory inShanghaiopened in 2023.At least seven other cultivated meat facilitieswere announced in 2023.Figure 1:Timeline of key cultivated meat updates in 20232023 State of the Industry Report/Cultivated meat and seafood7InvestmentsCultivated meat and seafood companies raised$225.9 million globally in

45、 2023,bringing the total forthe industry(since 2013)to$3.1 billiona fractionof the investments flowing into other technologiesand innovations,like renewable energy,with thepotential to reduce emissions and address climategoals.While the 2023 raises represent a sizabledecrease from the$922.3 million

46、raised in 2022,this mirrors the broader tepid private fundingenvironment.In 2023,companies and investors alike facedelevated inflation,rising interest rates,and amixed economic outlook.As a result,globalventure funding fell 42 percent year-over-year(YOY)in 2023 to its lowest levels since 2017(forcon

47、text,investments in foodtech startupsdeclined by 61 percent YOY).The largest dealraised in 2023 was Meatables$35 millionSeries B round.Meanwhile,the number of uniqueinvestors in cultivated meat and seafood totaled111 in 2023 compared to 204 in 2022.Table 1:Invested capital in cultivated meatCategory

48、20232022All-time(since 2013)2023 highlightsTotal investedcapital$226MM$922MM$3.1B83%of cultivated meat investmentoccurred in the last three years alone.Invested capitaldeal count53724162023s largest investment was$35MM(Meatable).Unique investors111204590The number of all-time uniqueinvestors grew by

49、 13%.Growth stagedeals(Series Band above)2213These included Meatable andBlueNalu.Source:GFI analysis of data obtained from Net Zero Insights platform2023 State of the Industry Report/Cultivated meat and seafood8Science and technologyNew studies expanded the industrys capacity toreduce costs,increase

50、 production scale,and improvethe quality of future products,while the researchecosystem continued to expand at universitiesaround the world,bolstering the long-term viabilityof the cultivated meat sector.Breakthrough research showed promisingimprovements to the taste,texture,andnutritional compositi

51、on of cultivated meat,bringing it ever closer to product parity withconventional meat.The examination of scalability and bioprocessdesign included one notable study thathighlighted several scenarios to bring cultivatedmeat to mainstream markets at price parity withconventional meat by reducing media

52、 costs,improving biomass yields,utilizing significantlylarger bioreactors,and exploring hybrid productapproaches.Multiple studies demonstrated that cell culturemedia can be produced at a much lower cost andwith much less environmental impact usingnon-animal ingredients and food-gradecomponents.Many

53、of these media can bemanufactured using agricultural cropby-products,thereby contributing to a morerobust circular bioeconomy.There were exciting advancements in thedevelopment of plant-,fungal-,and algae-basedscaffolds.The Alt Protein Project(APP)welcomed 24 newchapters(including expansions into co

54、untrieswhere APP was not previously represented,suchas Brazil,Japan,Malaysia,Portugal,Switzerland,and Turkey)and Tufts Universitybecame the first in the United States to offer anundergraduate minor in cellular agriculture.Government and regulationGovernments around the world supported cultivatedmeat

55、 in notable ways,from significant publicinvestment across several regions to the introductionand adoption of public policies favorable tocultivated meat to the U.S.Department ofAgricultures(USDA)approval for cultivated chickenin the United States.UPSIDE Foods cultivated chicken.Photo credit:UPSIDE F

56、oodsFor the first time,the COP28 climate conferencein Dubai spotlighted food system transformationas a major climate solution.China,Israel,Japan,the United Kingdom,theUnited States,and more supported the creationof new cultivated meat infrastructure and marketdevelopment.A report from the United Nat

57、ions EnvironmentProgramme(UNEP)focused on alternativeproteins,including cultivated meats potential tobenefit the environment and public health.The United Kingdom led 2023 cultivated meatfunding announcements with an allocation of12 million($15 million)for a new research hubat the University of Bath

58、followed by anestimated 3.4 million($4.3 million)for sevenresearch projects on cultivated meat.2023 State of the Industry Report/Cultivated meat and seafood9CommerciallandscapeCommercial landscapeOverviewAdvancements across the product,infrastructure,regulatory,and research landscapes made 2023 ahis

59、toric year for the cultivated meat and seafoodindustry.By years end,select cultivated meatproducts were sold to consumers in two countries,Singapore and the United States,with othercountries primed to follow.Further progress wasannounced in January 2024,when Israel becamethe third country in the wor

60、ld to advance theapproval of cultivated meat with the worlds firstcultivated beef product approval advancement forAleph Farms.New commercial developments in 2023demonstrated the growing depth and breadth ofcultivated foods:new facilities opened,representingall stages of the scale-up process;large co

61、mpanyinvolvement in cultivated meat deepened andexpanded into cultivated milk;and startups increasedtheir commitments to less-developed segments of thecultivated food value chain.Milestones representingdedicated effort from stakeholders across thecultivated meat ecosystem include:Following grants of

62、 inspection from USDA in2023,cultivated chicken products were sold toU.S.consumers for the first time by UPSIDEFoods and GOOD Meat at two restaurants:BarCrenn in San Francisco and China Chilcano inWashington,D.C.The number of publicly announced cultivatedmeat companies focusing primarily oncultivate

63、d meat inputs or end products rose to174 in 2023.In 2023,10 new cultivated meat productionfacilities opened,and several more wereannounced or began construction.In the UnitedStates,Believer Meats broke ground on a200,000-square-foot commercial cultivatedpork facility in North Carolina.This brings th

64、etotal number of cultivated meat productionfacilities to approximately 21 across the globe.Large food companies continued theirinvolvement in cultivated meat and dairy.JBS,the worlds largest meat company,beganconstruction on a center for cultivated meat inBrazil,and global food company Danone entere

65、dthe space for the first time with an investment incultivated milk company Wilk.Company landscapeIn 2023,the number of companies primarilydedicated to the development of cultivated meat andseafood inputs or end products exceeded 170,increasing from 166 in 2022.Additionally,at least 88other companies

66、 have been active in the industrythrough investments,partnerships,or cultivatedmeat business lines.An increasing number of companies are shiftingfocus toward areas of the cultivated meat valuechain beyond end-product formulation andmanufacturing,like bioprocess design,cell linedevelopment,and cell c

67、ulture media.Thisadvancement of the B2B ecosystem allowscompanies to focus on their core competencies and,over time,should allow the entire industry tofunction more efficiently.2023 State of the Industry Report/Cultivated meat and seafood11These figures may not fully capture the actual count of comp

68、anies involved in the cultivated meat space,asthere likely remain several startups in“stealth mode.”Additionally,while GFIs company database is intendedto be as comprehensive as possible,it is not exhaustive.Do you know of an alternative protein company thatsnot on our list?Request to add it here.Li

69、kewise,if you see a company in our database that has been acquired,closed,or rebranded,please let us know by requesting an update.Figure 2:Cultivated meat and seafood companies by year founded2023 State of the Industry Report/Cultivated meat and seafood12Figure 3:Distribution of companies by country

70、 and regionFigure 4:Number of companies involved in each technology focus area2023 State of the Industry Report/Cultivated meat and seafood13FacilitiesThe scale-up process for cultivated meat productionis frequently divided into four phases:lab scale,pilotscale,demonstration scale(industrial),andcom

71、mercial(commodity)scale.The pilot scaleserves as a crucial proof of concept,allowingcompanies and investors to assess raw material andproduction costs,as well as product yield.Facilities at the demonstration and industrial scalesproduce hundreds or thousands of kilograms ofcultivated product annuall

72、y.This means that,once aregulatory path to market is established,companiesare likely to have the capacity to supply a limitednumber of restaurants in the following one to threeyears,while also producing samples for regulatorsand key industry partners.In 2023,cultivated meat facilities opened,wereann

73、ounced,or broke ground in several regions,contributing to an expanding global supply chain.Notably,these new cultivated meat facilitiesspanned all four phases of the scale-up process.Not only are much larger facilities being built,butthe industry also continues to add lab-scale andpilot-scale facili

74、ties,meaning the cultivated meatfield is both expanding and progressing.Figure 5:Phases of cultivated meat scale up2023 State of the Industry Report/Cultivated meat and seafood14Facilities that opened in 2023Local governments in South Korea invested$7million to launch the first cellular agriculture

75、hubin the country.The North Gyeongsang CellularAgriculture Industry Support Center opened inMarch and houses laboratories,analysis rooms,quality control rooms,a research center,and fivecompanies.Cultivated pork company Fork and Good openedits 13,000-square-foot pilot facility in JerseyCity,NJ,where

76、the company is targeting costparity with conventional pork products.Israel-based cultivated meat company AlephFarms acquired VBL Therapeutics assets andtechnology from its pilot production facility inRehovot,Israel,and entered a newmanufacturing agreement with Esco Aster inSingapore.Mosa Meat,a cult

77、ivated meat company based inthe Netherlands,opened a 30,000-square-footproduction plant in Maastricht.The plant has thecapacity to make tens of thousands of burgerseach year from 1,000-liter bioreactors.Shanghai-based CellX completed theconstruction of its first large-scale cultivatedmeat factory,ca

78、lled Future Food Factory X(FX).FX will house multiple thousand-literbioreactors.Mosa Meat celebrates the opening of their cultivated meatproduction facility in Maastricht.Photo credit:Mosa MeatUK-based cultivated fat startup Hoxton Farmsopened a 14,000-square-foot pilot facility inLondon.The facilit

79、y has the capacity to produceup to 10 tons of cultivated fat per year.UK-based cultivated meat companyExtracellular opened a contract pilot facilitydedicated to cultivated meat and seafoodproduction in Bristol.The facility is the largest ofits kind in Europe and will provide development,scale-up,and

80、 manufacturing services.Meatable,a cultivated meat company based inthe Netherlands,opened a pilot facility toexpand the production of its cultivated porkplatform.The facility has a bioreactor capacityof 200 liters,with the ability to expand to up to500 liters.Australian cultivated meat company Magic

81、Valley expanded operations in a new pilot facilityat the Co-Labs incubator.The facility has 3,000liters of bioreactor capacity that can produce150,000 kilograms of product per year.Cultivated meat company SCiFi Foods built apilot plant in Californias Bay Area to producecultivated beef using cells ed

82、ited with CRISPRtechnology.Facilities that broke ground in 2023Believer Meats broke ground on a200,000-square-foot cultivated meat productionfacility in Wilson,North Carolina.The companyclaims the new facility will be the largest in theworld and will be able to produce at least 10,000metric tons of

83、cultivated meat per year.BioTech Foods,a subsidiary of JBS,brokeground on a commercial-scale cultivated meatfacility in Spain,which is set to be completed bymid-2024 and is designed to produce more than1,000 metric tons of cultivated beef per year.At least seven other cultivated meat facilities were

84、announced in 2023.2023 State of the Industry Report/Cultivated meat and seafood15Involvement bydiversified companiesMany of the largest meat and consumer packagedgoods(CPG)companies around the worldincludingJBS,Tyson,Cargill,Nestl,and Danoneareinvolved in the cultivated meat industry throughinvestme

85、nts,acquisitions,partnerships,and/orresearch,development,and manufacturing.Newactivity from diversified companies in 2023 indicatesa growing commitment to the cultivated meat sector.Large company involvement in the cultivated foodspace expanded beyond the meat sector in 2023 andinto areas like culti

86、vated milk,as both Danone andCentral Bottling Co.invested in Wilk.In 2023,French dairy company Danone agreedto a$2 million strategic investment deal withIsrael-based cultivated milk startup Wilk todevelop cultivated breast milk components forinfant formula.Central Bottling Co.,which ownsCoca-Cola Is

87、rael,also participated in the round,which totaled$3.5 million.In September 2023,JBS began construction ona$62 million research,development,andinnovation center for cultivated meat in Brazil.In 2022,Tyson Foods participated in a$36.5million Series A funding round for cultivatedmeat company Omeat,whic

88、h emerged fromstealth mode in 2023.Tyson invested incultivated meat companies UPSIDE Foods in2018 and Believer Meats in 2021.Table 2:Diversified companies with involvement in alternative proteinsSource:GFI analysis of publicly reported industry news and events2023 State of the Industry Report/Cultiv

89、ated meat and seafood16Table 3:Diversified companies with involvement in cultivated meat and dairySource:GFI analysis of publicly reported industry news and events2023 State of the Industry Report/Cultivated meat and seafood17PartnershipsCollaborations among research,production,and distribution part

90、ners are crucial to scale the cultivated meatsector.Here are some of the publicly announced partnerships from 2023:Table 4:Partnerships tableResearch and development partnershipsCompanies/organizationsDetailsJBS and the Federal University of Santa CatarinaCultivated meat research and development;con

91、sumerinsights studiesThe University of Alberta and New Harvest CanadaFormed the Institute of Cellular AgricultureProduct development partnershipsCompanies/organizationsDetailsCULT Food Science and Alcheme Bio Inc.Developing cultivated meat products using AICULT Food Science and JellaTechDeveloping p

92、et foods using cultivated collagenIvy Farm Technologies and FinnebrogueDeveloping cultivated Wagyu burgersNew Wave Biotech and MultusDeveloping cost-effective growth mediaPulmuone and Simple PlanetProducing cultivated meat and plant-based productsProFuse and GelatexImproving muscle tissue developmen

93、t on plant-basedscaffoldingSteakholder Foods and Umami BioworksDeveloping 3D-printed structured eel and grouperproductsUmami Bioworks and TriplebarDeveloping cell lines for cultivated seafood2023 State of the Industry Report/Cultivated meat and seafood18Scale-up partnershipsCompanies/organizationsDe

94、tailsADM and Believer MeatsRefining and expanding the cultivated meatproduction processAleph Farms and Thermo Fisher ScientificBuilding a growth media supply chainBlueNalu and NutrecoBuilding a food-grade supply chain for cultivatedseafoodCellX and TofflonBuilding a pilot facility and expanding R&D

95、capacityMagic Valley and BiocellionDeveloping more efficient bioreactorsMosa Meat and NutrecoDeveloping a cell-feed supply chainNewform Foods and Project AssignmentsBuilding a cultivated meat demonstration facilityOrbillion Bio and Solar BiotechScaling Orbillion Bios cultivated Wagyu beefORF Genetic

96、s and SeaWithAdvancing cultivated meat commercializationRe:meat and ICAEvaluating the market for cultivated meat in SwedenSeaWith and Esco AsterExploring SeaWiths proprietary microalgaetechnologies for cultivated meat projectsUmami Bioworks and Cell AgriTechDeveloping a cultivated seafood production

97、 facilityUmami Bioworks and Maruha NichiroBuilding infrastructure for Japans cultivated seafoodindustryVital Meat and BiowestScaling the production of cultivated meatDistribution partnershipsCompanies/organizationsDetailsBlueNalu,Mitsubishi Corporation,Pulmuone Co.Ltd.,and Thai UnionDeveloping a mar

98、ket strategy to launch BlueNalusproductsBlueNalu and NEOMAdvancing the commercialization,marketing,anddistribution of BlueNalus productsMarcus Samuelsson and Aleph FarmsSelling Aleph Farms cultivated products in the U.S.2023 State of the Industry Report/Cultivated meat and seafood19Product launchesU

99、PSIDE Foods launched its cultivated chicken atthe Bar Crenn restaurant in San Franciscofollowing USDA approval in June.Also following USDA regulatory approval in June,GOOD Meat began selling its cultivated chicken atthe China Chilcano restaurant in Washington,D.C.Hubers Butchery in Singapore became

100、theworlds first butchery to sell cultivated meat;itcarried GOOD Meats cultivated chickenthroughout 2023.Industry associationsAs the cultivated meat industry matures,tradeassociations and alliances can play important rolesin driving regulatory transparency,conductingconsumer research,and aligning on

101、nomenclature.In 2023,a group of academic and corporate partnersin Japans cultivated meat space created theConsortium for Future Innovation by CulturedMeat to promote cultivated meat manufacturingtechnology using 3D bioprinting.Dig deeper:Check out this blog post for an in-depth discussion on industr

102、y collaboration and take alook at a list of alternative protein trade organizations here.2023 State of the Industry Report/Cultivated meat and seafood20Consumer insightsConsumer insightsFor consumers interested in cultivated meat,2023was a pivotal year.Cultivated meat debuted onmenus in U.S.restaura

103、nts for the first time,althoughat only two locations.Singaporeans continued toenjoy cultivated meat as it expanded into a newsetting,a local butchery.The number of consumers who have sampled orpurchased cultivated meat,however,remains small,and the publics awareness and understanding ofcultivated me

104、at remains low.This means there isimmense potential to generate excitement aroundthe launch of the category,earn interest fromconsumers,and shape perceptions around theadvent of cultivated meat in global markets.While the consumer insights in GFIs 2022 State ofIndustry Report,Cultivated meat and sea

105、food,arestill broadly reflective of consumers sentiments andbeliefs about cultivated meat,new researchemerged in 2023 that deepened our understandingand points to emerging opportunities and challenges.Nomenclature andmessaging appealWhile GFI and many industry leaders have continuedto use the term“c

106、ultivated meat”to describe meatcultivated from animal cells,consumers continue tohear and use other descriptors.Terms such as“cell-cultured”and“lab grown”are still occasionallyused in the media.However,consumer researchsupports“cultivated”as the ideal name in terms ofappeal,clarity,comfort seeing it

107、 on packaging,andexpected personal use for consumers.A December 2022 U.S.general populationsurvey that GFI commissioned from EmboldResearch validated the use of“cultivated meat”over other terms.For a term consumers wouldlike to see on food packaging,twice as many U.S.adults selected cultivated meat

108、overcell-cultured meat.And four times as manypeople identified“cultivated”compared to“cell-cultured”as a term they could imagineusing personally.Overall,the research found that“cultivated meat”was an effective descriptor forthe category on differentiation from conventionalmeat,accuracy and descripti

109、veness,and appeal.A 2023 focus group study of Singaporeanconsumers who both had and had not eatencultivated meat suggests that the term“cultivated”is preferred in Singapore as well,byalmost twice the number of consumers as“lab-grown meat”(31 percent vs.18 percent).(Chong et al.)Another 2022 study by

110、 Malerich&Bryant of U.S.consumers found that“cultivated”prompted thehighest appeal and purchase intent of currentlyused names tested for most meat typesincluding chicken and salmon,thoughconsumers were more able to correctly identifythe products when“cell-”was appended.Together,this research support

111、s the continued useof“cultivated meat.”This term offers the strongestcombination of accuracy,ability to differentiate,anddirect consumer preference.Even with momentumbuilding around“cultivated meat,”researchers andcompanies should continue to test translationsacross languages,applications of preferr

112、ednomenclature,and explanations to the consumer.2023 State of the Industry Report/Cultivated meat and seafood22Consumer awareness,familiarity,and understandingBecause cultivated meat is still unfamiliar as a termand as a concept to many consumers,and othernames remain in use in some contexts,studies

113、 findvarying levels of awareness,familiarity,andunderstanding depending on how consumers areasked about it.Results overall suggest that mostconsumers are unaware and unfamiliar withcultivated meat.It will be crucial for the industry tobuild consumer awareness in the coming years.Awareness and famili

114、arityWhile levels of awareness vary based on howresearchers ask the question and which terms areused,comparison across studies suggests that around30 to 40 percent of the U.S.population has heard ofcultivated meat(GFI and Morning Consult found 40percent in 2023,and IFIC found 39 percent).The data fo

115、r familiarity reveals that only 10 to 30percent of consumers feel they are“very”familiarwith it(GFI and Morning Consult found eight percent“very”and 19 percent“somewhat”familiar in 2023,while Szejda et al.found 34 percent“somewhat”familiar and seven percent“very”familiar in 2021).Despite heightened

116、media attention and the limitedrelease of cultivated meat in two U.S.restaurants in2023,these numbers around consumer awarenessand familiarity have not increased significantly in thepast five years.This data suggests companies should considermarketing strategies that increase awareness,andultimately

117、 purchase intent,as they bring productsto market.Figure 6:Cultivated meat awareness across studiesSource:Anderson&Bryant 2018;Baumann&Bryant 2019;IFIC 2023;GFI 20232023 State of the Industry Report/Cultivated meat and seafood23Figure 7:Cultivated meat familiarity across studiesSource:Anderson&Bryant

118、 2018;Bryant&Szejda 2019;Baumann&Bryant 2019;Szejda&Bryant 2021;GFI 20232023 State of the Industry Report/Cultivated meat and seafood24Consumer willingness to tryFigure 8:Cultivated meat willingness to try across studies.Source:Anderson&Bryant 2018;Wilks&Philips 2018;Bryant&Dillard 2019;Baumann&Brya

119、nt 2019;GFI&Embold 2022;AP/NORC 2023;IFIC 2023Recent research suggests that significant numbers ofconsumers are willing to try cultivated meat and thatmore are becoming willing as they learn about it.In a pair of studies conducted by the InternationalFood Information Council in 2021 and 2023,thenumb

120、er of U.S.consumers who reported being“somewhat”or“very”interested in trying cultivatedmeat almost doubled from 24 percent to 42 percentover the two years between studies.While this isslightly smaller than the number of consumers whoare“not too”or“not at all”interested(51 percent),this trend is movi

121、ng in a positive direction.When presented with the hypothetical option to trycultivated meat,even more consumers signaled aninterest.Research by GFI and Embold Research in2022 found 45 percent were“willing to try cultivatedmeat if given a sample.”Other researchers inprevious years have found that nu

122、mber to be as highas 66 percent percent(Faunalytics 2018).While veryfew consumers in the United States can currentlyaccess cultivated meat(in 2023,it was served inonly two restaurants),signals for the potentialacceptance of cultivated meat are encouraging.2023 State of the Industry Report/Cultivated

123、 meat and seafood25Consumer willingness to try can also be brokendown into further categories:AppealA survey by conducted by Morning Consult on behalfof GFI in November 2023 found 32 percent of U.S.consumers rate cultivated meat as“very”or“somewhat”appealing after being given a shortneutral explanat

124、ion of cultivated meat(noting howits made,its similarity to conventional meat,andthat its available in the United States).Cultivatedmeat was rated as more appealing by omnivorousand flexitarian(meat-reducing)consumers.This is comparable to the rated appeal of other typesof alternative proteins.A GFI

125、 survey commissionedfrom Embold Research in December 2022 indicatesthat consumer appeal is higher when consumers areoffered an explanation of cultivated meat thatfocuses on its similarity to conventional meat,compared to explanations that emphasize novelty ortechnology.This suggests that highlightin

126、gcultivated meats similarity to conventional meat isthe most effective way to build favorability.Figure 9:Based on the description provided,how appealing or unappealing do you find cultivated meat?Percent of respondents who selected“very”or“somewhat”appealing,by dietSource:Poll by Morning Consult on

127、 behalf of GFI,n=2,203 U.S.adults November 2023Note:Results for pescatarians,vegetarians,and vegans not shown due to small sample size2023 State of the Industry Report/Cultivated meat and seafood26Figure 10:Likelihood to purchase or eat cultivated meat across studiesSource:Anderson&Bryant 2018;Wilks

128、&Philips 2018;Bryant&Dillard 2019;Baumann&Bryant 2019;Szejda&Bryant 2021;GFI 2023Purchase likelihoodA review of available research indicates thatbetween 30 and 50 percent of consumers say theywould be likely to regularly eat or buy cultivatedmeat.A November 2023 study conducted byMorning Consult for

129、 GFI indicates that 37 percent ofU.S.adults report being“somewhat,”“very,”or“extremely”likely to purchase cultivated meat.Thisis similar to the purchase likelihood of plant-basedmeat(46 percent in a poll by Morning Consult onbehalf of GFI,December 2023).Comparable levelswere seen by Szejda et al.in

130、2021 for consumers inthe United States and the United Kingdom,andresearch by ProVeg in 2022 for consumers in theUnited Kingdom saw similar rates at 35 percentlikely to try or buy.Research by Aleph Farms on 600consumers in Singapore in 2022(85 percent ofwhom were traditional omnivores and 14 percent

131、ofwhom were flexitarian)found that 71 percent saidthey would order cultivated meat“regularly”and 27percent“occasionally.”While its early in the marketlaunch of these products,these figures demonstratethe need to continue improving interest andpurchase intent with consumers,if companies aimfor cultiv

132、ated meat to reach mainstream adoption.Social motivationsA 2022 survey by Chong et paringSingaporean to American attitudes on cultivatedmeat found that greater acceptance of cultivatedmeat in Singapore was driven by stronger socialmotivations for food choices.While they attributethis to a Singaporea

133、n cultural trait of“kiasuism”(which they translate roughly as“FOMO”or fear ofmissing out),it is likely that consumers in othercountries will also become more open to cultivatedmeat as more people try it and share theirexperiences in social settings.2023 State of the Industry Report/Cultivated meat a

134、nd seafood27Consumer research anddemographic insights aroundthe worldMotivatorsIt is likely too early to tell how well claims andmessages about cultivated meat will resonate withconsumers.However,research has consistentlyshown that consumer interest in cultivated meat ispotentially driven by motivat

135、ors like health,curiosity,environmental benefits,and indulgencewithout sacrifice.The International Food Information Councils2023 survey on alternative proteins found thatcuriosity(32 percent),environmental benefits(28 percent),not requiring animal slaughter(28percent),and health(26 percent)were the

136、topreasons motivating consumers to try cultivatedmeat among those interested(with interestedconsumers selecting up to two reasons).Research in 2022 by GFI and Embold Researchfound that a wide variety of messages aboutcultivated meat increased consumers ratedappeal,including health(55 percent foundhe

137、alth messages made cultivated meatsomewhat or much more appealing);climatechange and environmental benefits(both 47percent);and offering the same and potentiallybetter taste,texture,and freshness thanconventional meat(also 47 percent).The healthmessage included both public health messagingaround red

138、uced risk of foodborne illness andpandemic,as well as personal health reasonslike lack of hormones,antibiotics,and steroids,suggesting that consumers are interested in avariety of personal and public health benefitsfrom cultivated meat.Research published in 2022 by GFI APACrevealed that the lack of

139、mercury and heavymetal contamination in cultivated seafood was atop driver of interest among consumers in Japan,Singapore,South Korea,and Thailand.The topbarriers across all four countries wereperceptions of taste shortcomings and concernsabout“freshness”and“naturalness.”DemographicsConsumer researc

140、h conducted by MorningConsult on behalf of GFI suggests that severalgroups in the United States are more likely tofind cultivated meat appealing,including men,Gen Z and Millennial consumers,and liberals.Omnivorous and flexitarian consumers are alsoespecially likely to find cultivated meatappealing,e

141、choing results from Singapore thatfound a majority of early adopters there wereomnivores and flexitarians,and suggesting thepotential for cultivated meat to appeal to themajority of consumers who are not currentlyeliminating conventional meat from their diets.Some evidence suggests that consumers ar

142、elikely to be persuaded by certain factors,including the recent USDA/FDA approval ofcultivated meat and by seeing others eat it.IFICs 2023 survey(conducted before theUSDA/FDAs approval in June 2023)found that63 percent of consumers think cultivated meatwould be safe if approved by USDA/FDA.2023 Stat

143、e of the Industry Report/Cultivated meat and seafood28Most effective messages to increase cultivated meat appealBased on a December 2022 survey of 1,018 U.S.adults by Embold Research commissioned by GFIPercentage of respondents who indicated that the message makes cultivated meat much more or somewh

144、atmore appealing to them:55 percentCultivated meat can be grown without added hormones,steroids,or antibiotics,in facilitieswith cleaner conditions than conventional meat processing facilities.This reduces the risk ofboth foodborne illnesses and future pandemics.47 percentCultivated meat is more env

145、ironmentally friendly than conventional meat.Producingcultivated meat requires much less water and land than the production of conventional meat.This means less competition for water in times of drought and the slowing of deforestation.Replacing conventional meat with cultivated meat will also reduc

146、e the amount of animalwaste created,resulting in less air pollution.47 percentAnimal agriculture is responsible for 20 percent of global greenhouse gas emissions.Replacing conventional meat with cultivated meat produced with renewable energy wouldresult in a massive reduction of greenhouse gas emiss

147、ions,helping to fight climate change.47 percentCultivated meat will have the same smell,texture,and consistency as the meat you enjoytoday.It will also taste the same or better than conventional meat given the productionmethods,it could have a purer taste and stay fresher longer.Finless Foods cultiv

148、ated sushi rolls.Photo credit:Finless Foods.Global perspectiveIn 2023,additional insights from around theworld provided further context for how cultivatedmeat is currently viewed by consumers and howits potential resonates.Studies from the United Kingdom(including byProVeg in 2022 and by Fidder and

149、Graa in2023)explored the power of imagery.Thesestudies found that images of cultivated meat thatshowcased its similarity to conventional meatled to a higher willingness to try and higherappeal ratings.The ProVeg study also found thatconsumers who were more familiar withcultivated meat reported seein

150、g it morefrequently associated with lab imagery,suggesting that there is enormous potential toimprove associations between appetizingimagery and cultivated meat.A 2022 survey in France of mostly youngconsumers(67 percent of the sample were aged18 to 30)found that 80 percent of consumersare open to t

151、rying cultivated meat and believe itwill become widespread.A total of 49 percent of consumers in Italy,Portugal,and Spain perceived meat as“promising and/or acceptable,”according to aJune 2023 study from Liu et al.The studyrevealed that 66 percent would be willing to trycultivated meat.In Poland,63

152、percent of adults“had heard ofcultivated meat”and 54 percent said“they wouldpurchase it when available,”according to aNovember 2023 study from Sikora and Rzymski.Figure 11:Based on the description provided,how appealing or unappealing do you find cultivated meat?Percent of respondents who selected“v

153、ery”or“somewhat”appealing by demographic groupSource:Poll by Morning Consult on behalf of GFI,n=2,203 U.S.adults November 20232023 State of the Industry Report/Cultivated meat and seafood30Gourmeys cultivated and pan-fried foie gras.Photo credit:Gourmey and Romain BuissonThe rise in misinformation a

154、nd disinformation about cultivated meat onlineBased on a November 2023 social media analysis by Changing Markets Foundation and Ripple ResearchA large social media analysis by Changing Markets Foundation and Ripple Insights in 2023 documented andcategorized the spread of misinformation on X(formerly

155、 Twitter)about meat and meat alternatives.They identifya small number of accounts(50)spreading misinformation about meat or meat alternatives,primarily focused ondisparaging meat abstention or alternatives(78 percent of content disparaged meat alternatives or abstentionwhile 22 percent promoted meat

156、).While the net percentage of engagement is small in terms of the population(two million interactions,measured in views,retweets,likes,shares,and comments),the content ismisrepresentative and raises unfounded concerns about meat alternatives that probably negatively affectedconsumer perceptions,espe

157、cially among those with less familiarity with the category.2023 State of the Industry Report/Cultivated meat and seafood31InvestmentsInvestmentsOverviewFollowing the first disclosed investment in cultivatedmeat and seafood in 2013,companies involvedprimarily in the cultivated meat sector have raised

158、$3.1 billion,with more than 80 percent ofinvestments coming in the last three years alone.While 2023 fundraising totals marked a decline from2022 levels,other primarily venture-backed sectorslike fintech also experienced funding declines ofaround 50 percent year-over-year(YOY).A GFI analysis of data

159、 from Net Zero Insights showsthat Cultivated meat companies raised$225.9million in 2023,representing a sizable decreasefrom the$922.3 million raised in 2022.Cultivatedmeat and seafood remain a nascent sector withfewer than 200 companies worldwide,approximately half of which were founded in the lastt

160、hree years.As a result,a small number of deals cansignificantly impact annual investment totals for thesector.For example,in 2022,nearly half of the yearstotal investment dollars were raised in UPSIDEFoods$400-million Series C round.Since advancedcompanies generally do not raise large rounds twoyear

161、s in a row,there is a degree of randomness inany single years funding totals.The cultivated meat and seafood sector lackedsimilar funding mega-rounds in 2023.The largestdeal raised in 2023 was Meatables$35 millionSeries B round,and the three largest investments forthe year totaled less than$100 mill

162、ion collectively.These are impressive totals for early-stage,pre-revenue companies,but without anymega-rounds raised,a much larger number ofsimilarly sized deals would have been required tokeep pace with recent years industry-wideinvestment totals.The wider alternative protein industry also sawpriva

163、te funding fall in 2023.While alternative proteincompanies raised$15.7 billion from 2014 to2023over half of which was raised in 2020 and2021investments dipped from$2.9 billion in 2022to$1.6 billion in 2023.That said,these totalsandthose for cultivated meat companiesare likelyunderestimated.Some comp

164、anies raised funds thatwere not publicly reported under simple agreementsfor future equity(SAFE)or bridge rounds to increasefinancial runway.While certain deals,in general,arenot publicly disclosed,we suspect an increasedfrequency of under-reporting this year based on thelarger number of SAFE and br

165、idge rounds and on ourconversations with market participants.Some ofthese investments may eventually be reported asinvestments in 2024.Various industries contended with a tepid privatefunding environment in 2023 driven by rising interestrates,elevated inflation,and a mixed economicoutlook.As a resul

166、t,global venture funding across allsectors fell 42 percent YOY in 2023 to its lowestlevel since 2017.Climate tech equity investmentsdecreased by as much as 40 percent YOY,despitethe sector receiving significant government supportthrough the Inflation Reduction Act and otherpolicies that helped to de

167、-risk and fuel investment.Investments in food tech startups declined by 61percent YOY.Even in the face of these challenges,the cultivatedmeat industry continued to advance in 2023.Consumers purchased cultivated meat products inthe United States for the first time,and severalcountries reviewed cultiv

168、ated meat products forregulatory approval.Companies also continued toinnovate their processes and products.The challenging private funding environment forcultivated meat and alternative proteins maycontinue in the year ahead,especially as interestrates in the United States,Europe,and elsewhere areli

169、kely to remain elevated in 2024.At the same time,alternative proteins and cultivated meat continue tobe among the most promising solutions for reducingthe negative impacts of conventional meatproduction.This also makes cultivated meat animportant ESG opportunity,providing potentialupside for investo

170、rs and the industry.2023 State of the Industry Report/Cultivated meat and seafood33With this backdrop,we expect alternative proteinand cultivated meat investments to evolve in thecoming years.Since 2023 was a year of majortransition,the industry is likely to settle on anadjusted,more realistic path

171、in 2024.In light of thetighter private funding environment that is expectedto persist into 2024,we expect the alternativeprotein companies best-positioned to attract equityinvestment will be those that can demonstrate clearpathways to revenue and profitability.At the sametime,long-term debt,grants,a

172、nd governmentincentives are essential for companies to lower theirproduction costs and achieve price parity as theyscale production.To enable alternative proteincompanies to access such funding,they will needcreative solutions in areas such as product off-takeand leveraging government and philanthro

173、picfunding.Fortunately,there are replicable solutionsalready being implemented(e.g.,school districtsprocuring alternative proteins for lunch menus)aswell as those that have been successfully used inother industries(e.g.,government loan guaranteesand blended philanthropic financing for renewableenerg

174、y).Through multi-stakeholder collaboration,these solutions can facilitate the flow of capital intoalternative proteins.Regardless of external market forces,if governmentsand companies are serious about improving foodsecurity,reducing emissions,and achieving theirclimate goals,more alternative protei

175、n funding isneeded to help companies scale,improve theirproducts,and reduce their costs.On that front,public funding for cultivated meat grew more robustin 2023,with governments investing in researchcenters of excellence,commercialization andinfrastructure programs,and targeted support forproducers.

176、Source:Unless otherwise cited,the investment datareported above was derived from GFIs analysis ofdata from Net Zero Insights.Note:Aggregated data has not been reviewed by NetZero Insights analysts.The total deal count includesdeals with undisclosed amounts.When things are easy,everyone can look bril

177、liant,but when times are hard,youneed to really look at what sets you out from the other areas.I,personally,andBarclays are very invested in the long-term of alt protein,and I think now is thetime for us to take a long-term perspective.Im excited about how far weve come and just because the capital

178、marketsoverall are at a rough time,we should not lose faith.The critical part is what thissector does for the planet and I think there it has some real longer-term returns.Matt SpenceManaging Director and Global Head of Venture Capital Banking at Barclays2023 State of the Industry Report/Cultivated

179、meat and seafood34Figure 12:Cumulative and annual alternative protein invested capital,by pillarSource:GFI analysis of data from Net Zero Insights.Note:Aggregated data has not been reviewed by Net Zero Insights analysts.Figure 13:Global equity financing across sectorsSource:(Alternative proteins,Cli

180、mate tech):GFI Analysis of data from Net Zero Insights;Aggregated data has not been reviewed by Net ZeroInsights analysts.Source:(Venture capital,Fintech):CB InsightsFigure 14:Cumulative and annual investment in cultivated meat and seafood(2014-2023)2023 State of the Industry Report/Cultivated meat

181、and seafood35Source:GFI analysis of data from Net Zero Insights.Note:Aggregated data has not been reviewed by Net Zero Insights analysts.Figure 15:Investments in cultivated meat and seafood by region(2014-2023)Source:GFI analysis of data from Net Zero Insights.Note:Aggregated data has not been revie

182、wed by Net Zero Insights analysts.The total deal count includes deals with undisclosed amounts.2023 State of the Industry Report/Cultivated meat and seafood36Figure 16:Investments in cultivated meat and seafood:Top 10 countries(2014-2023)Source:GFI analysis of data from Net Zero Insights.Note:Aggreg

183、ated data has not been reviewed by Net Zero Insights analysts.The top 10 countries were selected based on 2023 investedcapital.The total deal count includes deals with undisclosed amounts.Table 5:Deal type summary statisticsSource:GFI analysis of data from Net Zero Insights.Note:Aggregated data has

184、not been reviewed by Net Zero Insights analysts.These figures represent summary statistics of invested capitalrounds with disclosed deal amounts.Deal count includes rounds with undisclosed amounts.Due to their limited number and size,this tableexcludes angel,general crowdfunding,debt crowdfunding,gr

185、owth equity,private equity,private placement,and series D,E,G,and H rounds.Italso excludes uncategorized rounds.The total deal count includes deals with undisclosed amounts.2023 State of the Industry Report/Cultivated meat and seafood37Figure 17:2023 key funding roundsSource:GFI analysis of data fro

186、m Net Zero Insights.Note:“2023 key funding rounds”includes investments in the 75th percentile or higher by dollar amount for each funding round category thatincludes more than three deals.For funding round categories that include three deals or fewer,all deals are included.For a list of investors wh

187、o have expressed interest in funding cultivated meat and seafood,companiescan request access to GFIs investor directory.2023 State of the Industry Report/Cultivated meat and seafood38MethodologyGFI conducted a global analysis of cultivated meatinvestments using data from Net Zero Insights.Ouranalysi

188、s uses a list we built in Net Zero Insightsplatform of companies that focus primarily oncultivated products or on providing services to thosewho produce them.Types of companies included and excludedWe excluded the many companies that areinvolved in animal cell culture but not as theircore business,s

189、uch as Merck KGaA,Darmstadt,Germany,as the funding these companiesdevote to cultivated meat is undisclosed.We also exclude companies that are morefocused on plant-based or fermentation than oncultivated meatwe instead include thosecompanies in the area they are most involved in(e.g.,plant-based,ferm

190、entation).Some companies included in our list may alsooffer products or services that apply to anotherprotein category.The$200 million that Eat Justraised in March 2021 for use across theirproduct lines and the$267 million raised fortheir GOOD Meat division in the funding roundcompleted in September

191、 2021 are categorizedunder cultivated meat.All other Eat Just fundsraised are categorized under plant-based(thecompany was founded as a plant-based eggcompany,and their business is focused on bothplant-based eggs and cultivated meat today).Some companies use a different alternativeprotein production

192、 platform to produce inputsfor cultivated meat,for example using precisionfermentation to produce growth factors.Thosecompanies are categorized as fermentationcompanies and are excluded from our cultivatedmeat dataset.We included cultivated milk and eggcompanies as well as cultivated meat pet foodco

193、mpanies,though they are not the primaryfocus of this report.The Net Zero Insights platform contained 173companies involved primarily in the cultivated meatindustry,125 of which had disclosed deals.Of these,101 had deals with publicly disclosed amounts.NetZero Insights primarily tracks deals from pub

194、liclydisclosed sources unless companies claim theirprofiles on the platform and provide their owninvestment information.Because our aggregatecalculations include only companies with deals anddeal sizes available to Net Zero Insights,they areconservative estimates.Types of funding includedFor this re

195、port,invested capital/investment comprisesaccelerator and incubator funding,angel funding,bridge funding,convertible debt,corporate venture,equity and product crowdfunding,general debtcompleted deals,debt crowdfunding,seed funding,early-stage venture capital,late-stage venture capital,private equity

196、 growth/expansion,capitalization,jointventure,and private placements.Liquidity eventscomprise completed mergers,acquisitions,reversemergers,buyouts,leveraged buyouts,spinoffs,andIPOs,while other financing comprises completedsubsequent public share offerings and privateinvestment in public equity.We

197、do not include capitalraised through a SPAC IPO until the entity has mergedwith or acquired a target company.Data providerPlease note that the figures published in this reportmay differ from prior figures published by GFI,as weare now using Net Zero Insights as our investmentdata provider and are co

198、ntinually working to improveour dataset.To verify your companys data on theNet Zero Insights platform,claim your companysprofile here and help us ensure we have access tothe fullest,most up-to-date information.2023 State of the Industry Report/Cultivated meat and seafood39Liquidity eventsLiquidity e

199、vents represent the sale of an equityowners interest in a company,typically through amerger,acquisition,buyout,or IPO.In a relativelynascent category like the cultivated meat sectorwhere the vast majority of companies remain inpre-revenue stages,certain liquidity events such asmergers and acquisitio

200、ns(M&A)are more commoncomponents of industry development,while others,such as IPOs,are less common at this stage.Mergersand acquisitions allow companies with strongerfinancial footing to acquire firms with valuabletechnologies,manufacturing processes,and talent.That said,liquidity event activity is

201、also highlydependent on the broader economic context.No liquidity events,also known as exits,took place inthe cultivated meat sector in 2023.In a year when global M&A activity fell to its lowestlevel in over a decade,the relative lack of cultivatedmeat liquidity events was representative of the larg

202、erfunding and M&A environment.The same conditionsthat led to fundraising difficultieslike economicconcerns and a tight financing environmentalsocontributed to limited M&A activity.While we expect cultivated meat liquidity eventactivity to accelerate in the coming years,as seen inthe trajectories of

203、other transformative innovationslike electric vehicles,the rate at which it does so willalso hinge on conditions like interest rates,economicsentiment,and views of the cultivated meat sector.Other financingSome public companies pursue financing paths suchas subsequent public share offerings and priv

204、ateinvestment in public equity(PIPE)deals.The only cultivated meat and seafood company tohave raised such financing in 2023 is SteakholderFoods(previously MeaTech,which is traded publiclyon the NASDAQ stock exchange).According to NetZero Insights,the company raised$6.5 million inpost-IPO equity fina

205、ncing in January 2023.Oncemore cultivated meat and seafood companies begintrading publicly,we expect to see a higher number ofother financing rounds.The Good Food Institute is not a licensed investmentor financial advisor,and nothing in the State of theIndustry Report series is intended or should be

206、construed as investment advice.2023 State of the Industry Report/Cultivated meat and seafood40Science andtechnologyScience and technologyOverviewAs many companies march toward market readiness,a growing number of scientists in industry andacademia are exploring new lines of inquiry that willhelp red

207、uce costs,increase the scale,and improvethe quality of future products.As the rate of newlypublished research accelerates,the entire sectorbenefits from the growing foundation of open-accessinformation and discoveries that can be translatedinto the commercial realm.For a comprehensive view into the

208、current state ofthe science in cultivated meat,visit GFIs science ofcultivated meat page.Research across the sectorAs results for new cell lines and culture conditionsare published each year,more research groups haveexpanded their focus into scaling up production withsmall bioreactors,using scaffold

209、ing to culture cells in3D,and creating prototype products that can beanalyzed for taste,texture,and nutrition.With theseadvances,a growing number of scientists arefocused on product safety and quality,while othersare exploring the potential environmental andsocietal effects of a future with a growin

210、g marketshare of cultivated meat.This section provides a snapshot of notable scientificadvancements from 2023.Cell linesDefinition:For cultivated meat and seafood to match the variety of conventional products on the market,high-quality cell lines from many species will be required.A variety of cell

211、types may be applicable tocultivated meat,from pluripotent stem cells to adult stem cells capable of becoming fat,muscle,orconnective tissues.Researchers are working to develop and characterize new cell lines and to betterunderstand the properties of different cell typesgrowth potential,metabolism,m

212、edia requirements,andeffects on the properties of the final productthat will determine how suitable each cell type is forcultivated meat.2023 research highlightsThe cultivated meat research community continuedto expand the availability of high-quality cell lines forresearch and commercialization.To

213、betterunderstand cultivated meat companies needs whenit comes to cell lines,GFI APAC conducted anindustry-wide survey and developed a report withkey insights into:the species and cell types ofhighest priority;the methods currently used for cellline development,characterization,and growth;andregulato

214、ry documentation and testing.A new muscle cell line from the freshwater carpLabeo rohita was described by a team that includedGFI grantees Dr.Mukunda Goswami and Dr.RezaOvissipour.Another muscle cell line from oliveflounder was described by researchers at PukyongNational University.Besides muscle,pr

215、oducing awhole cut of meat like a steak or a chicken breastrequires producing different cell typesincluding fatcellsand a 3D structure for their growth.Researchers from Nanjing Agricultural Universityreported the derivation of a new immortalizedporcine(pork)fat cell line,including theco-differentiat

216、ion of muscle and fat cells on the2023 State of the Industry Report/Cultivated meat and seafood42same scaffolds.If such processes can be scaledeffectively,they have the potential to increase theresemblance of cultivated products to theirconventional counterparts and substantially simplifythe product

217、ion process.Additionally,researchers from Aleph Farmsdescribed their approach to bovine embryonic stemcell line development and characterization.Embryonic cells such as these could be used as thestarting point for muscle,fat,and any other cell typedesired by cultivated meat producers.Collectively,th

218、ese studies fill many of the knowledge gaps aboutthe cells being used in cultivated meat productionand expand the repertoire of cell lines available forresearch.It was also an exciting year for B2B cell linedevelopment.GFI has identified 65 lines(up from 41 in2022)relevant for cultivated meat that c

219、an be orderedfrom public repositories or directly from the cell lineowner,many of which are owned by B2B providers suchas OpoBio,QuestMeat,Roslin Technologies,andPluriCells.In addition,the contract manufacturerExtracellular announced the creation of a new,license-free cell bank for the cultivated me

220、at industry inpartnership with Multus Media.Beginning with primary muscle and fat cells fromcows,pigs,and lambs,Extracellular plans to expandto additional species and tissues.Cultivated meatcompany Ohayo Valley also indicated their intentionto pursue a partial B2B model as a supplier ofcustom cell l

221、ines.Finally,a partnership betweenbiotechnology company Triplebar and cultivatedseafood company Umami Bioworks was alsoannounced this year to accelerate cultivated fish cellline development.Triplebar presented theirtechnology at GFIs Cultivated Meat CollaborativeSeminar in late 2022.Cell Culture Med

222、iaDefinition:Cell culture media contains the nutrients and growth factors needed to cultivate cells outsidethe body.As the primary input into the cultivated meat process,it is currently the largest cost andenvironmental impact driver of cultivated meat production.Additional research is needed to der

223、iveanimal-free formulations that match the metabolic requirements of each cell line,in addition to creating asupply chain of more affordable,animal-free,and food-grade ingredients.2023 research highlightsApproaches to research in cell culture media haveincluded removing animal components and replaci

224、nghigh-cost ingredients with more affordablealternatives,optimizing the efficiency of media usewithin the production process,and enabling the useof fewer overall media ingredients.In 2023,companies made progress along various points ofthis research pipeline.One promising approach uses waste streams

225、fromone industry as feedstock into another,which canimprove both cost and sustainability metrics.GFIand collaborating researchers explored the potentialuse of sidestreams from commodity crops in NorthAmerica for cultivated meat production,finding thatsoybean meal,corn distillers dried grain,canolame

226、al,brewers spent grain,and corn gluten mealcould all be good candidate sources for hydrolysatesto supply amino acids for cell culture media.The ultimate goal in using crop sidestreams is toreplace serum and to more affordably andsustainably supply nutrients to cultivated cells.Researchers have alrea

227、dy begun to investigate this2023 State of the Industry Report/Cultivated meat and seafood43concept,with groups in South Korea and Singaporefinding that fermented soybean meal and okara,awaste stream from tofu and soy milk production,could potentially be used as a serum alternative.Several studies al

228、so explored using compoundsextracted from cyanobacteria and extracts fromdifferent species of microalgae,finding that thesecould be a beneficial supplement to cell cultures.However,challenges remain,including optimizingthe protocols for obtaining hydrolysates or extracts.In one study,researchers at

229、the University ofCampinas in Brazil tested various enzymes andconditions to discover how to maximize the yield ofpeptides and amino acids from soybean and peanutprotein meals.Future studies that optimize protocolsfor raw material extracts and hydrolysates will becrucial for the cultivated meat indus

230、try,and theresearch into reducing the cost and environmentalimpact of cell culture media using availablealternatives remains promising.Other notable research focuses on optimizing theoverall media formulation and ensuring that it isused efficiently.Recent research on this topic usedmathematical tech

231、niques and algorithms to optimizemedia costs and reduce environmental impact,aswell as to derive serum-free media that outperformsserum-containing media.Media formulation discovery can also be enhancedthrough systems biology and metabolic modelingtechniques,which are increasingly important as thecul

232、tivated meat industry matures.Collectively,theseefforts can accelerate the development of cultureconditions across a variety of species and cell typesused to cultivate meat,enabling an easier startingpoint for new labs and companies entering the field.However,to date,most media research has focusedo

233、n mammalian and avian cells,and mediaoptimization for seafood continues to be a majorbottleneck.Finally,the field saw progress in 2023 on anotherknown challenge:preventing the buildup of toxicmetabolites such as ammonia.Potential methods foraddressing this issue range from adsorption togenetic engin

234、eering to altering the mediacomposition.Researchers at Mosa Meatdemonstrated the latter approach,showing thatammonia production can be kept at a minimum bychanging what cells are fed,a simple solution thatcould potentially have a large impact if adoptedthroughout the industry.2023 State of the Indus

235、try Report/Cultivated meat and seafood44ScaffoldingMany approaches to producing cultivated meat use some form of 3D scaffolding to provide structure to thefinal product;facilitate nutrient,oxygen,and waste transport;and provide cues that can help the cellsdifferentiate and mature as desired.Research

236、 into scaffolding for cultivated meat focuses on identifying thebest materials(or combinations of materials)and developing innovative manufacturing technologies forscalable and cost-effective scaffolds.2023 research highlightsResearch into scaffolding for cultivated meat focuseson identifying the be

237、st materials(or combinations ofmaterials)and developing innovative manufacturingtechnologies for scalable and cost-effectivescaffolds.One key theme for 2023 was the use of biomaterialsderived from plants,fungi,and other sustainablesources as cultivated meat scaffolds.Traditionally,tissue engineering

238、 has relied heavily onanimal-derived proteins such as collagen or onsynthetic polymers as scaffolds.Todays cultivatedmeat researchers are proving that there is plenty ofuseful scaffolding functionality to be found in theplant and fungi kingdoms if we know where to look.Researchers at Boston College

239、and WorcesterPolytechnic Institute used decellularized plantmaterial from existing waste streamsspecificallycorn husks and jackfruit rindsas microcarriers.Withan eye toward improving the applicability ofdecellularization-based techniques to cultivatedmeat,the same team also tested methods forreplaci

240、ng the traditional solvents and detergentsand identifying conditions where effectivedecellularization could be achieved using food-safecompounds.Researchers from the Sanjay GandhiPost-Graduate Institute of Medical Sciences(India)demonstrated that decellularized mushroomscould be successfully used as

241、 scaffolds formyoblasts(muscle precursor cells).Similarly,researchers from A*STAR performed abioinformatics analysis that found that the RGDmotif,an amino acid sequence known to beimportant for the adhesion of animal cells to theextracellular matrix,was common among bothplants and fungi.They also de

242、monstrated thatRGD-rich protein extracts from fungi comparedfavorably to the animal-derived matrix proteinscollagen and fibronectin,thereby adding furtherevidence that plants and fungi show promise asscaffold sources for cultivated meat production.Researchers from the National University ofSingapore

243、 determined that pumpkin seed proteinsupported cell adhesion and proliferation to a similarextent as animal gelatin and could support long-termproliferation of mouse muscle and fat cells,adhesionof chicken and pig muscle cells,and muscle celldifferentiation.They also confirmed that pumpkinseed prote

244、ins are rich in RGD sequences,whichpresumably explains their results.A second paper bythe same group found that chickpea protein,despiteperforming poorly when untreated,was highlyeffective at supporting adhesion,proliferation,anddifferentiation when used as a hydrolysate.Andwhereas alginate is usual

245、ly observed to have poorcell adhesion properties,a study by researchers fromKonkuk University,NoAH Biotech,and SeoulNational University demonstrated that theseproperties could be modified by altering thecrosslinking conditions.A great deal of diversity exists within plant-,fungal-,and algal-derived

246、biomaterials,including propertiesthat are beneficial for cultivated meat scaffolds.Through a combination of bioinformatic and empiricalscreening for desirable properties and careful testingof the conditions by which scaffolds are created,researchers in 2023 identified food-safe scaffold2023 State of

247、 the Industry Report/Cultivated meat and seafood45materials that support cell adhesion and proliferationwith positive or neutral effects on flavor,texture,andnutritional properties of the final product.These findings collectively validate the hypothesisthat animal-derived materials will not be neces

248、saryto create cultivated meat products in the future.Bioprocess designDefinition:The bioprocess for cultivated meat encompasses production lines of bioreactors outfitted withsensor equipment,integrated with cell-harvesting and food-processing equipment,and designed withautomation in mind.Production

249、lines can be constructed in various ways,and research is needed todetermine the best-suited bioreactors and technologies required to create and scale a spectrum ofcultivated meat product types.2023 research highlightsCompanies are actively employing a variety of celllines to cultivate muscle and fat

250、 for many products,ranging from fish and shrimp to beef,chicken,andpork.However,there are still challenges in closingthe knowledge gaps,optimizing cell cultureprotocols,and developing and selecting suitablebioreactors.To achieve price and taste parity,there are severalareas in the field of bioproces

251、sing that researchers,suppliers,and investors can tackle,includingaddressing the high costs and limited availability ofmedia components,raw materials,and bioreactors.Key areas requiring further research anddevelopment include improving the cost andaccessibility of bioreactors,using food-grademateria

252、ls,and developing other fit-for-purposeequipment such as for cell harvesting.Additionalareas include training professionals in bioprocessing,modeling,simulation,and automation.Cultivated meat bioprocessing saw several notableadvancements in 2023.Ark Biotech published atechno-economic analysis highli

253、ghting the potentialof current biomanufacturing technologies to producecultivated meat at scale at an estimated price of$29.50 per pound.The report outlines fourstrategies to further lower the cost of goods sold:reducing media costs,improving biomass yields,optimizing the bioprocess,and utilizing la

254、rgerbioreactors.According to the report,media is themain contributor to costs,and lowering its cost toaround$1 per liter is essential for cultivated meat toreach price parity.Another insight from the report isthe importance of scaled production,which enablesa lower cost burden of depreciation and la

255、bor.The analysis also compares scenarios using differentbioprocess methods,favoring fed-batch orcontinuous processing for cost-effectiveness.Whilefed-batch processing was found to be superior inmost cases of scaled production,continuousprocessing requires less overall capital expenditureand space.In

256、 conclusion,Ark Biotech emphasizesthe need for integrated advancements across media,bioreactors,cells,and bioprocesses to achieve priceparity with conventional meat.Researchers from Norway and the Netherlandsenhanced the cost-effectiveness and efficiency ofcultivated meat production by focusing on t

257、uning andoptimizing media components and cell cultureparameters.The group was able to expand skeletalmuscle satellite cells for up to 38 days underserum-free conditions in a bench-scale bioreactor.This approach highlights the potential for optimizingvarious parameters specific to each cell line andb

258、ioprocess,thereby reducing costs and increasingyields while removing the reliance on fetal bovineserum(FBS).2023 State of the Industry Report/Cultivated meat and seafood46Cultivated meat production shares some challengesand opportunities with fields like regenerativemedicine,highlighting the potenti

259、al forcollaborative efforts and resource allocation.Regenerative medicine can contribute insights intoareas such as developing scaffolds for tissuegeneration,stem cell biology,or media development.Bioreactorspivotal in both healthcare andcultivated meat manufacturingenable efficiencyand scalability

260、by expanding cell culture andproviding controlled conditions for cell growth.Thisreview explores and assesses bioreactor technologyin cell therapy and cultured meat production.To address the challenges associated with 3D culturefor cultivated meat production,a team of scientists inFrance has develop

261、ed an innovative solution.Traditional 3D culture methods often rely on scaffoldsthat are not easily scalable.In response,theresearchers created an in vitro culture system thatcombines the benefits of biomimetic 3D culture withscalable bioreactor-based production.The studysuccessfully scaled up the p

262、roduction of stem cellsand demonstrated scale-independent expansionyields,reaching an impressive 277-fold expansion injust 6.5 days in a 10-liter stirred-tank bioreactor.While these results were demonstrated in humancells,this concept could rationally be translated forthe cultivated meat industry.Fi

263、nally,using computer models and simulations is crucialfor optimizing cultivated meat processing and achievingcost parity,particularly at large scales.One majorchallenge in this process is the disruptive shear stresscaused by high rotor speeds in bioreactors.In a recentstudy,researchers developed a c

264、omputational modelintegrating agent-based modeling and computationalfluid dynamics to examine biomass growth instirred-tank bioreactors.Their focus was to understandhow mechanical stress induced by rotor speed impactscell growth on spherical microcarriers.The simulationresults aligned with physical

265、experiments,demonstrating that elevated rotor speeds reduce cellgrowth rates and increase cell death due to highmechanical stresses.This simulation was the first step inbuilding comprehensive models that can improvebiomass production and reduce costs by informingbioreaction design and culture condit

266、ion optimization.End-product formulation andcharacterizationCommercial success for cultivated meat will requireboth the development of efficient and reliablebioprocesses and a clear understanding of what goesinto making a tasty and nutritious product.To thatend,with every passing year,the inclusion

267、of flavor,texture,and nutritional characterization in academicpapers on cultivated meat is becoming more routine,specifically for:fat profiles(Yuen Jr.et al.2023;Louis et al.2023);texture profiles(Xu et al.2023;Yen et al.2023;Guan et al.2023;Liu et al.2023;Zhu et al.2023);and changes to the product

268、inresponse to cooking(Yen et al.2023;Kawecki et al.2023;Guan et al.2023).Methods for the characterization of cultivated meatproducts are expected to borrow heavily from thoseused for conventional meat.For example,a review byMariano et al.(2023)discusses the use ofcharacterization methods for the aut

269、hentication andtraceability of cultivated meat to validate anddifferentiate it from conventional meat.A key question that the cultivated meat field isbeginning to grapple with is how can cultivatedmuscle and fat be most effectively combined into acohesive tissue?Co-culture of myogenic(muscle)and adi

270、pogenic(fat)cells may be complicated due totheir different media requirements and theirtendency to influence one anothers activity.However,it appears that this is not aninsurmountable obstacle and successfulco-differentiation of pork fat and mouse muscle cellshas been demonstrated.Alternative approa

271、ches that do not requireco-differentiation have also been validated.Forexample,one study showed that pre-differentiatedfat and muscle constructs could be combined toform a cohesive tissue,and another created aprototype by combining differentiated muscleconstructs with a plant-based oleogel.Furtherre

272、search is needed to identify and ensure the mostefficient approaches for bioprocess efficiency andproduct quality.2023 State of the Industry Report/Cultivated meat and seafood47Nutrition and taste parityIn 2023,GOOD Meat received clearance from FDAand USDA,setting the stage for greater scalability,r

273、educed manufacturing costs,and a moreeco-friendly product.In GOOD Meats dossiersubmitted to support the safety of their cultivatedchicken,they compared the nutritional value of theircultivated chicken with that of conventional chicken.This report demonstrated that 100 grams ofcultivated chicken had

274、a similar nutritional profile,including total protein,fat,and carbohydrate levels,to conventional chicken.GOOD Meats cultivated chicken has a lower caloricvalue than conventional chicken breast,as thecultured cells have a higher moisture content.Thecultivated chicken had similar monounsaturated fat,

275、saturated fat,and cholesterol levels as theconventional chicken breast.Adipose(fat)tissue is crucial to the flavor of meatproducts.Recent research showed thatadipose-derived stem cells can differentiate into fatcells,and that by adjusting the fatty acidcomposition of the culture medium,the cells cou

276、ldcreate the qualities of real muscle fat.Although cultured fat has the potential to significantlyenhance the quality of alternative protein products,the production of macroscale tissues continues to beconstrained due to the delivery of oxygen andnutrients to larger tissues.One team has developed am

277、ethod to produce macroscale fat tissue suitable forfood applications.The team resolved the challengesof macroscale tissue engineering and 3D cell cultureby first growing adipocytes on 2D surfaces and thenforming 3D tissues after the cells underwentadipogenesis.Unlike regenerative medicine,cultivated

278、 meat doesnt require ongoing cell viabilityonce the final macroscale fat tissue is created,thusopening up more options for developing the finaltissue structure.Also in 2023,Vow applied to Food StandardsAustralia New Zealand(FSANZ)to secure approvalfor cultivated quail cells made from Japanese quaile

279、mbryonic fibroblasts as a novel food.FSANZconducted a comprehensive hazard and riskassessment covering microbiology,biotechnology,toxicology,nutrition,and dietary intake.Theirpublished report in December 2023 concluded thatthe cell line is genetically stable,microbiologicalhazards are low,and there

280、are no safety concernsregarding exposure to production processsubstances or food allergenicity.There was nodetected gluten,and there were no identifiednutritional risks.Overall,FSANZs assessmentsupports the safety and approval of Vows culturedquail cells as a novel food.Food safety and public health

281、New safety dossiers from GOOD Meat in the UnitedStates and Vow in Australia and New Zealandbecame publicly available in 2023.Encouragingly,both products are made without antibiotics,containno detectable heavy metals,and are free fromcommon foodborne pathogens such as E.coli andSalmonella.Overall,the

282、se documents are also a richresource for understanding how quality control ofcell lines and media is performed and the keyconsiderations for regulators when evaluating safety.GFI Brazil and collaborating scientists at theUniversity of Campinas released a report thatoutlines a food safety plan for a

283、hypotheticalcultivated burger production process based onHazard Analysis and Critical Control Points(HACCP)principles.This report,together with theaforementioned safety dossiers,provides anexcellent overview of the safety considerations andhazard mitigation strategies for the production ofcultivated

284、 meat.At the multinational level,the FAO published asummary report from a stakeholder meetingconvened in Israel in 2022 and hosted anothermeeting in China in 2023.At these meetings,cultivated meat companies presented to localregulators,providing a deeper understanding ofproduction processes and safe

285、ty considerations.The Singapore Food Agency convened a roundtablemeeting with more than 250 participants to discuss2023 State of the Industry Report/Cultivated meat and seafood48how to approach risk assessment for novel foodssuch as cultivated meat,as well as how to harmonizeregulatory frameworks an

286、d increase informationsharing around the globe.Following the meeting,theAPAC regulatory coordination forum was announcedwith the aim of contributing toward the same goal ona regional level.Finally,with H5N1 avian flu crossing into severalmammalian species in 2023,some experts began tohighlight the p

287、otential for cultivated meat to helpmitigate these zoonotic disease threats.If cultivatedmeat can substitute for conventional meat in futurediets,it could substantially mitigate risks ofantibiotic resistance and zoonotic disease associatedwith industrial animal farming.Environmental and social impac

288、tThe UN Environment Programme(UNEP)released alandmark report in 2023 that assessed the potentialimpacts of alternative proteins on public health andenvironmental harms compared to animal agriculture(summarized here).The report cites numerous lifecycle assessments(LCAs)of cultivated meat,whichcollect

289、ively show how cultivated meat requiressignificantly less land,results in lessnitrogen-related impact such as less air pollutionand less eutrophication,and could produce fewergreenhouse gas emissions than conventional meat,especially if renewable energy is used.In 2023,headlines were briefly dominat

290、ed by apreprint study from University of California,Davisscientists which claimed cultivated meat could havea carbon footprint many times higher than that ofconventional beef,significantly diverging from theexisting literature.GFI and other scientists refutedfindings from a preprint study from UC Da

291、visscientists that diverged from existing literature.GFIfound that the studys assumptions(which resultedin claims that cultivated meat could have a carbonfootprint many times higher than that ofconventional beef)do not accurately reflectpractices in the industry.GFI asserts that morerealistic estima

292、tes of the carbon footprint ofcultivated meat can be found in existingpeer-reviewed studies.A new study from researchers at Iowa StateUniversity showed that cultivated meat has highercaloric energy and protein productivity per unit areaof land compared to conventional meat.But sincetreating wastewat

293、er is costlier than manureapplication,media recycling will become importantin managing nitrogen as the industry scales up.Another study led by researchers at Tufts Universityassessed the impacts of recombinant growth factorsused in cell culture media,aligning with otherstudies that suggest their con

294、tribution to overallimpacts can be high despite being used in smallquantities.Given the importance of LCA studies,GFI publishedan LCA guide that provides a standardized approachfor commissioning and conducting studies,as wellas interpreting and leveraging their results.Understanding the potential im

295、pacts of cultivated meaton society will become increasingly important ascultivated meat matures.A study from Asia Research&Engagement described how the adoption of alternativeproteins in Asia is critical for meeting its sustainabilitygoals.It describes how this transition will require aconcerted eff

296、ort between the public and privatesectors,with ramifications that could drasticallychange the landscape of agriculture across numerouscountries.Further to this concern,a summary reportfrom a 2022 workshop was published.The workshophosted cultivated meat companies,research labs,dairyfarms,animal righ

297、ts organizations,and indigenouscommunities,and the report contains numerousinsights on how a just and equitable transition can bereached among diverse communities.A similar study summarized discussions with focusgroups with farmers in the United Kingdom.Somefarmers perceived opportunities,such as gr

298、owinginputs for the cell culture media,but many farmersperceived cultivated meat as a threat to farmingtraditions and livelihoods.Overall,the study highlightsthe importance of including farmers perspectives indiscussions related to cultivated meat.2023 State of the Industry Report/Cultivated meat an

299、d seafood49Scientific ecosystemIncreasing the number of people involved incultivated meat projects around the world is criticalto solving R&D challenges and ensuring that enoughtalented professionals are entering the workforce asthe industry grows.An assessment of the number ofpublications and publi

300、c research funding dollars,combined with other signals,reveals that thescientific ecosystem continued to grow steadily.The upward trajectory of the number ofcultivated meat-focused scientific publicationscontinued in 2023(see figure 19).Notably,several of the recent papers have come fromcultivated m

301、eat companies,including Mosa Meat(Hubalek et al.2023,Melzener et al.2023a,Melzener et al.2023b,Martins et al,Messmer etal,Caponi et al),Aleph Farms(Zehorai et al.2023,David et al),OpoBio(Jin et al.),andCultimate Foods(Kirsch et al).Publications bycompanies,or by academicindustrycollaborative teams,a

302、re an important ingredientin the success of the cultivated meat fieldbecause they signal the realization that successcomes not from knowledge silos withinindividual companies but from an open andcollaborative effort to solve shared problems.Public sector funding is critical for building thescientifi

303、c foundation to grow new ideas,spawnnew technology,and train new scientists andengineers.Although significantly more fundingis needed,more government funding agenciesare realizing the potential of cultivated meat toaddress critical challenges,and public fundingdollar totals have been steadily increa

304、sing YOY.Additionally,many of these awards,such as theCellular Agriculture Manufacturing Hub in theUnited Kingdom,represent multimillion dollarcommitments involving universities andcompanies alike.A new program at Tufts University now enablesstudents to earn an undergraduate minor incellular agricul

305、turea first for the field.Theprogram consists of six classes,including aresearch-based course,and is yet anotherexample of how cellular agriculture is maturingas a field.The Alt Protein Project welcomed 24 newstudent groups from across the globe in 2023.Student leaders from the Alt Protein Projectco

306、ntinue to drive change at theiruniversitiesfrom developing courses toorganizing community events to conductingoriginal research.After graduation,the skillsdeveloped in the Alt Protein Project help to setstudents up for meaningful careers inalternative proteins.2023 State of the Industry Report/Culti

307、vated meat and seafood50Figure 18:Cultivated meat research funding by year and sourceSource:GFI Research Grants TrackerFigure 19:Papers about cultivated meatSource:GFIs alternative protein literature library.Note:Reviews refer to analyses of previously published work,whereas research articles refer

308、to newly conducted experimental work.Preprintsrefer to manuscripts that are released online prior to peer review.Preprints that have been subsequently published are not included in this figure.2023 State of the Industry Report/Cultivated meat and seafood51Resources for scientistsGFI supports the cul

309、tivated meat industry bycreating open-access tools and resources that makescientists jobs easier.Free tools and resourceslaunched or substantially updated in 2023 include:Solutions database.GFI continued to build asolutions database this year,including newentries on synergistic climate and biodivers

310、itybenefits of alternative proteins,fit-for-purposebioreactors,naturally adhesive scaffoldingmaterials,seafood cell lines,and alternativesurimi written by research fellow Dr.MattMcNulty.This database captures ideas forresearch projects,commercial ventures,orecosystem solutions that have the potentia

311、l toaccelerate the development andcommercialization of alternative proteins.Thoselooking to get involved or looking for a newproject can find ideas and inspiration there.Literature library.GFI maintains an alternativeprotein literature library tracking publicationsabout or relevant to cultivated mea

312、t and otheralternative proteins.In addition to keeping thelibrary up to date with this years most influentialpapers,GFI added a new feature in 2023:theend product tracker.This resource makes it easyto find details on experiments characterizing theflavor,texture,nutrition,and more for cultivatedmeat

313、prototypes described in academicliterature or documentation submitted bycompanies to regulators.Trends in cultivated meat scale-up andbioprocessing.An upcoming GFI report willsummarize a survey conducted in early 2023 on 30cultivated meat companies and suppliers,aimed atunderstanding the current bio

314、processing,production capacities,and challenges faced bycultivated meat manufacturers worldwide.Itcollected information on infrastructure,productioncapacities,food safety practices,andbioprocessing details at various stages ofproduction.This report provides an overview of thecurrent and future needs

315、 of the cultivated meatindustry.It identifies key insights for investors,highlights essential research and developmentopportunities,and outlines critical considerationsfor suppliers in this evolving sector.Cell line survey.GFI APAC published a reportsummarizing a survey they conducted to betterunder

316、stand what cell types cultivated meatcompanies are using,where the biggest cellline-related pain points are,and how GFI andothers can better support this growing industry.Seafood differentiation pathways review.Together with several collaborators,GFIpublished a review paper in MarineBiotechnology ex

317、ploring what is known about thepathways involved in the differentiation andmaturation of meat-relevant cell types in fishand aquatic invertebrates,and the implicationsfor cultivated seafoods next steps.Cultivated seafood white space workshop.InJanuary 2023,GFI held a workshop with expertsfrom academ

318、ia and industry that explored thechallenges associated with culturing fish cellsand how the field of cultivated seafood can moreeffectively move forward.The report describeskey takeaways from those discussions,whichhelped us refine our topic selection for theResearch Grants Program RFP later in the

319、year.Fish&CHIPS.In response to participantfeedback from the white space workshop,GFIpiloted a new cultivated seafood event seriescalled the Collaborative Huddle for Ideation&Problem Solving,or Fish&CHIPS.These online,discussion-based workshops bring the cultivatedseafood community together,foster po

320、tentialnew collaborations,and offer an opportunity forcollaborative problem solving and knowledgesharing.Upcoming huddles can be found on ourevents page,and are tentatively scheduled forMarch,July,and November 2024.Science of cultivated meat.GFI continuedrefreshing our series of cultivated meat tech

321、nicalexplainers,focusing on a technical deep dive intocultivated meat cell lines.2023 State of the Industry Report/Cultivated meat and seafood52GFI Brazils massive open online course(MOOC)MOOC.We recorded updated videos in our freemassive open online course(MOOC)to packagethe lectures into shorter,m

322、ore accessiblesegments.This resource is a digestible startingpoint for learning about alternative proteins,including cultivated meat and seafood.Researcher directory.If youre a researcher in thefield,find collaborators and increase the visibilityof your work by joining the recently revampedalternati

323、ve protein researcher directory.Cultivated meat collaborative seminars.GFIhosts an invitation-only monthly seminar forscientists in the cultivated meat industry.Solutions providers present their technology,with the goal of establishing new collaborationsthroughout the industry.While some presenterso

324、nly make their material available to liveattendees,many of these recordings are nowavailable on GFIs YouTube channel.LCA guide.Our new LCA guide provides anoverview of best practices for conducting lifecycle assessments,which are increasinglyimportant tools for understanding andcommunicating environ

325、mental impacts and foridentifying key levers for continued sustainabilityimprovement.TEA review.GFI collaborated with Next RungTechnology to write a chapter on performingtechno-economic analyses for cultivated meatfor the new textbook Advances in Cultured MeatTechnology,which includes comparativeana

326、lyses of the cultivated meat TEAs publishedto date.Assuring the safety of cultivated meat.In thisreport,GFI Brazil and collaborators outline thefirst steps of a food safety plan for a cultivatedburger production process based on HazardAnalysis and Critical Control Points principles.Sidestreams analy

327、sis.This new analysis exploreshow sidestreams from the cultivation ofcommodity crops can be used in alternative proteinproduction,including as sources of hydrolysatesfor cultivated meat cell culture media.2023 State of the Industry Report/Cultivated meat and seafood53Government andregulationGovernme

328、nt and regulationOverviewIn 2023,a handful of governments made significantprogress in supporting the development of cultivatedmeat.This progress included allocating new fundingto the sector through research and developmentprograms,infrastructure development,taxincentives,and more.As the planet exper

329、ienced record hightemperatures in 2023potentially breaking a125,000-year-old recordgovernments allocatedfunds from climate and sustainability programs todevelop cultivated meat,including in the UnitedKingdom and Spain.Cultivated meats potential tobenefit the environment and the climate wasconfirmed

330、in a report from the United NationsEnvironment Program(UNEP)in December.Andnotably,the COP28 climate conference in Dubaifocused on food system transformation as essentialfor meeting global climate goals for the first time.Policymakers considered not only cultivated meatsglobal benefits but also the

331、economic andtechnological benefits it could bring within nationaland sub-national borders.The United States,theEuropean Union,China,the United Kingdom,Japan,Israel,and more supported cultivated meatinfrastructure and development for the newmarkets and jobs they are expected to bring.These government

332、s also supported researchers andcompanies by establishing new institutions,grants,and incentives.As bioeconomies increasinglyemerged as priorities in national development plans,cultivated meat and its cross-benefits areincreasingly considered not just an environmentalsolution but also a strategic an

333、d economicinvestment for meeting country-level food security,public health,and economic goals.Global public fundingAmericasPublic investment in cultivated meat research anddevelopment accelerated in the Americas in 2023.New research projects were announced in Brazil andthe United States,including a project to develop ahybrid plant-based and cultivated sausage atBrazilian state research agency Embr