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1、山东省高养殖密度地区某正压空气过滤猪场9年蓝耳疫情回顾A Nine-year Retrospective Study on PRRS Epidemic in A Positive Air Filtration Pig Farm in Shandong Swine Dense Region李月田 Yuetian Li健康管理部经理 Pig Health Management Manager提纲Outlines正压空气过滤系统简介Introduction to positive air filtration systemGGP场在正压空气过滤系统运行下历年生产成绩Production perfor
2、mance of GGP farm in past years under the operation of positive air filtration system2016年4月和2021年5月两次通过部分清群法快速净化蓝耳病The PRRS was rapidly eradicated by partial depopulation in April 2016 and May 202117年11月全群感染后通过封群净化蓝耳病The farm was infected with PRRSV in November 2017,which was eradicated by the LCEG
3、GP五周节律,一点式生产 five-week batch production,one site正压空气过滤猪舍,垂直通风 Positive air filtration with diffuse ventilation system猪瘟、伪狂犬、口蹄疫抗原阴性,蓝耳双阴 Antigen negative for CSF,PRV,FMD.Antigen and antibody negative for PRRS体系内供料,深井水,配清水清设备 Self owned feed mill,deep well water with Chlorine treatment为体系内提供精液和种猪 Pro
4、vide semen and breeding stock for the production system图1.场区分布图Figure 1.Regional distribution of pig farm图2.栋舍分布图Figure 2.House distribution背景 Background:背景 Background:独立空气过滤间,全场7组过滤器,每组3层过滤器(外层三防网G3,2层亚高效过滤器F7、F9)The air comes from 7 air filtration boxes with 3 levels air filters,wind protection ne
5、tting G3,prefilter F7 and main filter F9.图3.空滤间Figure 3.Air filtration room 图4.过滤器Figure 4.Filters 背景 Background:空气通过3层过滤器进入风道,空气垂直通过进气口平均进入房间通过漏粪板进入出风道,房间空气通过出风道汇集到出气间排出栋舍The air filtered comes through 3 levels air filter to the air duct,air enters the room vertically through the ceiling air inlet
6、and enters the air outlet through the slat,the air in the room was exhausted through the air outlet under slat.图5.进风通道Figure 5.Air inlet图6.垂直通风Figure 6.Vertical ventilation图7.出风通道Figure 7.Air outlet背景 Background:压力表:第一层G3压强差不高于60帕,第二层F7压强差不高于200帕,第三层F9压强差不高于340帕,空滤间滤效不低于85%Pressure sensor:The differ
7、ential pressure for first layer G3 shouldnt be above 60 pa,for second layer F7 shouldnt be above 200 pa,for third layer F9 shouldnt be above 340 pa,the filtration efficiency should be higher than 85%.0%10%20%30%40%50%60%70%80%90%100%3月4日3月11日3月18日3月25日4月1日4月8日4月15日4月22日4月29日5月6日5月13日5月20日5月27日标准85%1
8、号机组2号机组3号机组4号机组5号机组6号机组7号机组图8.压力监测Figure 8.Pressure monitoring表1.滤效监测Table 1.Filtration efficiency monitoring材料与方法 Materials and Materials and MethodsMethods:对比聚落内正压空气过滤GGP场和非空滤PS场蓝耳发病情况 Comparison of the infection rate of PRRS between positive air filtration GGP farm and conventional negative venti
9、lation PS farm in same cluster.统计分析2013年投产后正压空气过滤GGP场的生产成绩 The key production performance of the positive air filtration GGP farm since the start up of 2013.部分清群法对蓝耳病的快速净化 Rapid eradication of PRRS by partial depopulation.蓝耳双阴场全群感染蓝耳病后,通过封群净化策略,实施McREBEL管理措施,抗原抗体监测,三年后再次净化为双阴场及经济学分析 The farm turned
10、to be antibody negative herd 3 years later by LCE approach after PRRS infection,and the disease economy was evaluated.结果与分析 Results and Results and Analysis:Analysis:蓝耳发病情况:PS场平均每年1-2次,正压空气过滤GGP场平均3年1次The occurrence of new PRRSV infection:PRRSV was introduced to PS farm 1-2 times per year,and 1 time
11、 per 3 years to positive air filtration GGP farm.图9.聚落内猪场分布Figure 9.Distribution of pig farms within the settlement图10.发病情况Figure 10.Diseases process结果与分析 Results and Results and Analysis:Analysis:0.020.040.060.080.0100.0120.00050060070016/05/3116/09/3017/01/3117/05/3117/09/3018/01/3118/0
12、5/3118/09/3019/01/3119/05/3119/09/3020/01/3120/05/3120/09/3021/01/3121/05/3121/09/3022/01/31月母猪存栏量Monthly sow inventory分娩率Farrowing rate0.02.04.06.08.010.012.014.016.018.016/05/3116/09/3017/01/3117/05/3117/09/3018/01/3118/05/3118/09/3019/01/3119/05/3119/09/3020/01/3120/05/3120/09/3021/01/3121/05/312
13、1/09/3022/01/31活仔数BA死胎数SB木乃伊MB流产Abortion84.0%86.0%88.0%90.0%92.0%94.0%96.0%98.0%2000212022上市率Market rate正品率Rate of certified products正压空气过滤系统下生产成绩稳定The production performance of positive pressure air filtration system is stable图11.月度基础母猪存栏Figure 11.Monthly sow inventory图12.产仔和流
14、产Figure 12.Farrowing performance and abortion 图13.空气过滤场肥猪出栏上市率Figure 13.Market rate of weaned pigs from the farm结果与分析-第一次部分清群Results and Results and Analysis-1Analysis-1stst partial partial depopulationdepopulation2016年4月10日育成舍1611010批后备猪(148日龄)转群前检测蓝耳抗体阳性,复检阳性。On April 10,2016 the 1611010 batch gil
15、ts (148 days old)in GDU were tested positive for PRRS antibody before entering the main herd,the retest was positive.PCR抗原阳性,外部实验室复检阳性 The third party lab validated positive for PRRS.全场摸排感染范围,结果显示仅发生在育成舍 Fortunately the virus was only found in GDU.确定出猪通道,保育及育成猪只全部出场 The nursery and growing pigs were
16、 moved out of the farm through dedicated corridor.消毒静置 The nursery and growing unit were emptied and disinfected后续监测 The follow-up monitoring结果与分析 Results and Results and Analysis:Analysis:持续监测其它区域蓝耳抗原、抗体全部阴性,成功快速净化蓝耳病Antigen and antibody were tested for negative in other units,the PRRS was eradicat
17、ed rapidly.经济损失:后备种猪种用价值丧失Economic loss:gilts were sent to slaughterhouse as finishers图14.处理路线Figure 14.Processing route图15.通道布置Figure 15.Delivery vehicle结果与分析-第二次全群感染Results and Results and Analysis:-2Analysis:-2ndnd whole herd whole herd infectioninfection2017年11月23日生产公猪出现20头不食少食,采集鼻拭子检测猪流感、血样检测蓝耳
18、抗原、抗体和伪狂犬gE抗体20 collecting boars off feed were tested for SIV,PRRS and PRV gE antibody on November 23rd,2017.11月25日异常猪只血样蓝耳抗原、抗体阳性,公猪舍确诊感染蓝耳病Both antigen and antibody positive for PRRS,the boar stud was confirmed PRRS positive on November 25th,2017.12月7日基础母猪出现不食少食,采集血液检测蓝耳抗原、抗体均为阳性。基础母猪确诊感染蓝耳病Sows o
19、ff feed were tested for PRRS.Both antigen and antibody positive,the sow herd was confirmed PRRS on December 7th,2017.12月20日 育肥舍出现不食少食,采集血样检测蓝耳抗原、抗体均为阳性。保育育肥确诊感染蓝耳病Finishers off feed were tested for PRRS.Both antigen and antibody positive,the nursery finisher herd was confirmed PRRS on December 20th,
20、2017.结果与分析 Results and Results and Analysis:Analysis:连续监测24头皮杜公猪的精液恢复情况,62%的公猪精液质量在感染野毒后4周恢复,8周内全部恢复The semen quality was evaluated weekly for 24 pietrain duroc boars.The semen quality of 62%boars recovered 4 weeks post infection,others were recovered 8 weeks post infection.连续监测33头皮杜精液排毒,20%公猪没有影响(采
21、精间隔7天)对于阳性的精液转阴时间最短12天,最长100天以上The virus shedding of boars were evaluated for 33 pietrain duroc boars.20%boars showed no virus shedding.The shortest shedding interval was 12 days while the longest was up to 100 days.图16.精液排毒时间Figure 16.Semen virulence time7371315621.21%9.09%21.21%3.03%9.09%3.03%15.1
22、5%18.18%0123456781-10天11-20天 21-30天 41-50天 51-60天 61-70天 71-80天 100天数量比例图17.精液质量恢复时间Figure 17.Semen quality recovery time3354332112.50%12.50%20.83%16.67%12.512.50%8.33%4.17%01234560周2周3周4周5周6周7周8周数量比例结果与分析 Results and Results and Analysis:Analysis:12月17日-次年2月11日,流产风暴持续2个月,流产32头超出标准28头The abortion st
23、orm started from 17th December to 11th Feb.32 sows aborted in total in 2 months,28 sows much more than the standard.影响4个批次断奶母猪的准胎率和分娩率,发病后基础群配种数量应该增加3个批次,每个批次15%The conception rate and farrowing rate decreased in the following 4 batches,farm breed 15%more sows for next 3 batches.0/01/16/0
24、4/16/07/16/10/17/01/17/04/17/07/17/10/17/12/18/04/18/07/18/09/18/12/19/03/19/06/19/09/19/12/20/03/20/06/20/09/20/12/21/03/21/06/21/09/21/12/22/03/22/06/90.3599.0495.0994.7395.3296.4295.6596.5591.0890.977.7792.3873.4576.9292.3893.4496.4695.888.5998.193.1487.7293.4686.6191.393.182.188.1864.177.163.774
25、.391.486.860657075808590951001701001批1703002批1704003批1705004批1706005批1707006批1708007批1710008批1711009批1712010批1801001批1802002批1803003批1804004批1806005批1807006批 准胎率图18.周流产数Figure 18.Abortion per week图19.分娩率与准胎率Figure 19.Farrowing rate and conception rate结果与分析 Results and Results and Analysis:Analysis:产
26、仔情况影响3批,窝均活仔12头下降到8头,断奶前死淘影响3个批次平均增加20%The live born per litter decrease from 12 to 8 and last for 3 batches.The PWM increased 20%for 3 batches.0.00%5.00%10.00%15.00%20.00%25.00%30.00%35.00%40.00%0.002.004.006.008.0010.0012.0014.0016.0018.001707006批1708007批1710008批1711009批1712010批1802002批1803003批180
27、4004批1806005批活仔数BA死胎数SB木乃伊MB死胎SB%木乃伊MB%9.610.710.28.73.86.76.49.910.321.921.018.019.158.826.524.115.418.10.010.020.030.040.050.060.070.00.02.04.06.08.010.012.01707006批1708007批1710008批1711009批1712010批1802002批1803003批1804004批1806005批断奶仔猪数Weaning number断奶前死亡率%rate before weaning图20.产仔情况Figure 20.Farrow
28、ing performance图21.断奶数和断奶前死淘率Figure 21.Weaned per litter and PWM结果与分析 Results and Results and Analysis:Analysis:曲*户该批猪水平传播感染,死淘率由正常水平2-3%增加到5%The N-F mortality of 1st batch weaned pigs after PRRS increased from 3%to 5%due to lateral PRRSV transmission.001-003批为宫内感染,死淘率高达20%以上The followed 3 batches w
29、ere infected by sows in utero,the mortality was up to 20%.批次Batch当前日龄The current day 成活率Rate of survival4.55%1%2.63%2.77%.84%0%养户Farms进苗日期Date当前日龄The current day 死淘率Mortality丛*2018/6/25340.36%姜*2018/5/19712.35%于*2018/4/131058.79%张*201
30、8/3/814017.75%陈*2018/2/317528%曲*2017/12/282105%表2.场内批次死淘率Table 2.On farm batch death rate表3.场外养户批次死淘率Table 3.Mortality of contracted farmers 结果与分析 Results and Results and Analysis:Analysis:感染后第5批睾丸液开始转阴,第6批睾丸液和弱仔猪血样抗原全部转阴The processing fluid of 5th batch piglets test for negative,the processing flui
31、d and weak piglet serum both negative for 6th batch piglets in June,2018.检测时Detection time检测样品The sample type检测项目Test item检测结果Detection result17年12月25日010批20份血样PRRS Ag阳性18年1月25日 001批30份血样PRRS Ag阳性18年3月1日002批30份血样PRRS Ag阳性18年4月2日 003批30份血样,2份睾丸浸出液PRRS Ag血样阳性(1/6)、阴性(5/6),睾丸浸出液阳性18年5月10日004批30份血样,2份睾丸
32、浸出液PRRS Ag血样阴性,睾丸浸出阳性(1/2)、阴性(1/2)18年6月17日005批血样33份,2份睾丸浸出液PRRS Ag血样阴性,睾丸浸出液阴性表4.仔猪血样、睾丸液PRRS检测情况Table 4.PRRSV detection results of blood and processing fluid of piglets结果与分析 Results and Results and Analysis:Analysis:18年6月后基础群抗原监测全部阴性 The basal herd were tested negative for antigen after June,2018.一
33、点式保育育肥带毒时间远超基础母猪,应该考虑尽早清群防止场内病毒循环While the nursery finisher herd tested positive for antigen for long time.图22.抗原监测情况Figure 22.Antigen detection结果与分析 Results and Results and Analysis:Analysis:生产公猪27个月抗体阳性率衰减到15%,基础母猪35个月抗体阳性率衰减到6%,保育育肥38个月抗体阳性率衰减到3%The antibody positive rate of boars decreased to 15
34、%after 27 months.For sows was 6%after 35 months.For nursery finisher herd was 3%after 38 months.一点式双阴场感染蓝耳野毒后通过封群净化自留后备的方法至少40个月才可以净化成功(双阴)It took at least 40 months for one site farm to recover to antigen and antibody negative for PRRS by LCE and on site gilt production.图23.抗体监测情况Figure 23.Antibody
35、 detection结果与分析 Results and Results and Analysis:Analysis:繁殖损失流产损失窝数32实际流产28标准流产4窝均断奶数5.6流产损失断奶猪数320死胎木乃伊损失30%实际S/M40%标准S/M10%死胎木乃伊损失断奶猪数900期间分娩窝数200窝均总仔15合计损失断奶猪数1220收入损失(元)600,000头均收入500保育育肥损失期间断奶猪数422死亡率增加13%实际在途死淘率15%标准在途死淘率2%保育育肥损失猪数55利润损失(元)27,500头均利润500免疫保健成本增加繁殖群免疫成本(元)17,820疫苗单价*免疫头份*繁殖群药物成
36、本(元)75,000药物单价*药物数量*保育育肥免疫成本(元)6,836疫苗单价*免疫头份*保育育肥药物成本(元)6,330头均药费增加15保健头数422免疫保健成本(元)105,986收益损失733,486头均基础母猪收益损失1705 基础母猪存栏430表5.全群感染经济学分析Table 5.Economic analysis of whole population infection结果与分析-第二次部分清群Results and Results and Analysis-2Analysis-2ndnd partial partial depopulationdepopulation202
37、1年5月31日育肥转后备转群前,2101001批次采血测蓝耳、猪瘟、伪狂犬gE/gB、口蹄疫抗体2101001 batch gilts were tested for PRRS,CSF,PRV gB and gE antibody,FMD antibody before entering on 31st May,2021.发病原因追溯:过滤器率效低于70%Cause:Filter rate efficiency is less than 70%蓝耳抗原、抗体阳性,蓝耳病仅发生在保育育肥舍 Antigen and antibody positive for PRRS.PRRSV was only
38、 found in nursery finisher barn.生产公猪精液停止使用,但按批次正常排精/采血,检测非洲猪瘟抗原、蓝耳抗原抗体、伪狂犬gE抗体 The boars were collected while the semen were not allowed for AI.The boars were tested for ASF,PRRS,PRV in the followed 3 weeks.配怀舍母猪停止调群 The sow movement was stopped in breeding barn.产房生产操作正常执行 The farrowing rooms operat
39、e as usual.结果与分析 Results and Results and Analysis:Analysis:基础母猪群、生产公猪,抗原抗体全部阴性,蓝耳病毒未扩散到母猪区和公猪区The sows and boars were tested negative for PRRS.本次疫情成功处置The PRRS was eradicated by partial depopulation.经济损失:后备种猪种用价值丧失Economic loss:gilts were sent to slaughterhouse as finishers图24.出猪路线Figure 24.The rout
40、e of pig departure图25.出猪情况Figure 25.The scene of the pig departure结果与分析 Results and Results and Analysis:Analysis:2013年2014年2015年2016年2017年2018年2019年2020年2021年2022年投产第一次蓝耳病部分清群净化成功第二次蓝耳病全群感染第三次蓝耳病部分清群净化成功保持蓝耳双阴性36个月引入野毒保持蓝耳双阴性19个月引入野毒净化成双阴40个月保持双阴性3个月至今保持双阴性20个月经济损失:保育、育成猪群种用价值丧失经济损失:保育、育成猪群种用价值丧失经济
41、损失:每头母猪1705元,40个月无法产生蓝耳双阴种猪间隔43个月再次引入野毒结论与讨论 Results and discussion 在中国北方高密度养殖区域,空气过滤系统对于蓝耳防控有效,对比没有空气过滤系统的猪场蓝耳发病频率降低了80%The air filtration system can decrease the PRRS infection rate in Northern China high swine dense regions.The infection rate was 80%lower than conventional negative ventilation fa
42、rm.空气过滤系统下,可以通过部分清群的方式实现蓝耳的快速净化,空气过滤系统真正实现了猪场的最小单元格可以有效防止气溶胶栋舍间的传播 The PRRS can be eradicated by partial depopulation rapidly due to the isolated air space minimize the aerosol transmission within farm.通过封群驯化的方式6个月后生产出蓝耳抗原阴性仔猪,但要实现抗原抗体阴性需要40个月的时间 It took 6 months to produce PRRS negative weaned pigl
43、ets but took 40 months for the farm to turn to antibody negative.在高密度养殖区域,平均36个月引入一次蓝耳新毒株,进行经济学测算,空气过滤系统投入产出比是可观 The new PRRSV infection occurred every 36 months in high swine dense regions.The air filtration system is economic efficient.研究的局限性在于仅选取了一个场进行分析,国内使用亚高效空气过滤系统的猪场有限,数据需要完善 Due to the late application of air filtration farm in China,the data is limited.致谢 Acknowledgements:李曼中国养猪大会Leman China Swine Conference美国迦太基兽医服务公司 Carthage Veterinary Service,LTD环山养猪事业部健康管理团队 Huanshan Pig Health Management Team