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1、免疫力“新利器”?是时候曝光维生素D全新密码了!2023-06-15Dr.Jim Richards 全球科学事务副总裁,人类营养与关怀事业部,帝斯曼-芬美意集团Stella Liu大中华区市场与商务拓展总监,人类营养与关怀事业部,帝斯曼-芬美意集团For Internal Use Only2We are dsm-firmenichInnovators in nutrition,health and beautyPerfumery&BeautyTaste,Texture&HealthHealth,Nutrition&CareAnimal Nutrition&HealthFor Internal
2、Use Only3Proven science that improves livesTodays challenges demand visionary solutionsWith over a century of world-class scientific leadership,we apply creativity and proven science to tackle complexity using the broadest portfolio of ingredients in our industry 15R&D facilitiesdeveloping solutions
3、 for key global markets2,000+of the best and brightest scientists and engineers16,000+patents across approximately 2,600 patent families700m+in annual R&D investmentFor Internal Use Only4Supports immunityVitamin D supplementation reduces the risk of acute respiratory tract infectionsVitamin D plays
4、a role in the innate and adaptive immune response.Sufficient vitamin D status has been linked to reduced risk for infections(acute respiratory tract,sepsis,tuberculosis).Vitamin D is a fat-soluble vitamin that supports many important functionsSupports healthy pregnancies Vitamin D supplementation du
5、ring pregnancy reduces the risk for low birth weight and reduced the risk for gestational diabetes.Vitamin D supports placental tissue,foetal growth.Sufficient vitamin D status is essential for healthy pregnancies.Supports muscle strengthVitamin D supplementation has a positive impact on muscle stre
6、ngthVitamin D is essential for muscle cell contraction and proliferation in muscle tissue.Sufficient vitamin D status is essential for healthy muscle strength Supports healthy bonesVitamin D helps your body to absorb calcium and phosphorus.Vitamin D helps to reduce the risk of falling which is a ris
7、k factor for bone fractures among men and women 60 years of age and older.Neural tissuesVitamin D may have a neuroprotective role.Supports healthy blood sugar managementVitamin D is involved in pancreatic insulin production and sensitivity and glucose uptake in tissues.Supports healthy blood pressur
8、eVitamin D plays a supportive role in regulating normal vascular tone and blood pressure.Sufficient vitamin D status has been linked to healthier blood pressure.For Internal Use Only5Inadequate vitamin D levels worldwide are an ongoing health concern168,389 participants from the general population M
9、ean serum 25(OH)D 88.1%insufficient according to the Endocrinology Society (mean values below 75 nmol/L or 30 ng/mL)37.3%insufficient according to IOM(mean values below 50 nmol/L or 20 ng/mL)6.7%of the population deficient(mean 25-OHD values 18 years old supplemented with calcifediol or matched untr
10、eated controlsComparison shown is those supplemented with calcifediol who reached 25(OH)D levels of at least 75 nmol/L(n=16,276),vs.unsupplemented controls with 25(OH)D levels less than 50 nmol/L(n=7616)Outcomes were Covid infection,severe Covid,and Covid mortalityP0.001P=0.001P0.001Oristrell et al.
11、(2022)J Endocrinol Invest 45:167-179.For Internal Use Only15图.年龄及其地域与维生素D不足之间的关系。维生素D严重缺乏:25(OH)D=25-羟基维生素D 30 nmol/L;维生素D缺乏:3050 nmol/L;维生素D不足:5075 nmol/L;维生素D充足:75 nmol/L中国居民随着年龄增加维生素D缺乏状态越严重11 Liu et al.(2021)Vitamin D status in Mainland of China:A systematic review and meta-analysis.EClinicalMed
12、icine 38(2021)101017105项研究,234,519名受试者。在成人中,是总体平均值25(OH)D浓度为44.3 nmol/L;VitD缺乏和不足分别为20.7%和63.2%儿童和青少年25(OH)D的总平均浓度为52.2 nmol/LVitD不足的患病率随着年龄的增长而增加在中国大陆,低VitD状态在一般人群中很突出,尤其是成年人。2021 Meta-analysis1:维生素D缺乏维生素D不足A中国居民维生素D状态(2021 年)For Internal Use Only挑战是什么呢?日照时间不够!16需要一种起效更迅速的维生素D形式来源,尤其针对免疫功能的需求 有限的阳光
13、照射 防晒霜 深色皮肤 在室内久坐不动的生活方式 除了营养强化,很少有食物是良好的维生素D来源 缺乏天然来源维生素D的饮食 纯素食 常规的维生素D补充剂需要几个月才能达到需要的水平维生素D摄入不足长时间可达到最佳水平For Internal Use Only17引进具有强大竞争优势的维生素D品类的新营养元素Ampli-D是一种生物可利用的维生素D形式,已被证明可以带来维生素D的所有好处,比以往维生素D更快、更可靠。最佳的维生素D状态与更强的免疫健康和更低的病毒感染风险有关。ImmunityImmunityImmunityImmunityampliampli-D D 是一个吸收速度快吸收速度快3
14、 3倍倍以及更有效的维生素D D剂型剂型Ampli-D是您身体需要的营养素补充剂,可以更快地将维生素D提高到最佳水平,并更好地吸收必需的维生素D。Ampli-D是你必需的阳光维生素,帮助你达到最佳的维生素D水平,并支持健康的免疫力。我们从太阳,食物和营养素补充剂中获得维生素D它在肝脏中被转化骨化二醇known as ampli-D它在肾脏中被转化最佳的维生素D水平支持免疫健康骨化二醇,又称钙化二醇,是人体内最常见的维生素D形式。它的生物利用度也更高,因此比普通维生素D更容易被身体吸收。这有助于更快地达到最佳维生素D水平。ampli-D是DSM的骨化二醇产品,临床证明优化维生素D状态比普通维生素
15、D快3倍。正常情况下,人体需要几个月的时间才能达到最佳的维生素D水平For Internal Use Only这是维生素D市场上脱颖而出的方法18*For raising Vitamin D3 status as measured by circulating calcifediol ampli-D compared to vitamin D3 mcg/mcgPotential claims are for informational purposes only and are not intended to take the place of independent advice and c
16、ounsel by the customers own and/or locally hired experts in the fields of Regulatory Affairs,Nutrition Science,and Legal Affairs.Customer shall rely solely on its own experts for advice and recommendation in these fields.For further assistance,please contact your DSM account manager.对比声称 更快、更可靠的维生素D
17、形式*更快更有效的维生素D形式 更快的提高维生素D水平*更快达到最佳维生素D水平 补充维生素D*最优生物利用度的形式 代谢率最高的维生素D形式*最高效的维生素D形式*更有效地提高维生素水平 更可靠的提高维生素D水平机制声称 直接提高维生素D水平/维生素D状态 机体可立即获得并利用 体内自然产生 是体内循环形式的维生素D 不需要经过肝脏代谢,减轻肝脏负担 弥补因VD代谢相关基因遗传变异对VD水平的影响消费者友好高质量和技术性能 依据最高质量标准生产于美国和瑞士 2年的货架有效期 具有多维,复合钙加D以及片剂的应用及稳定性数据强有力的科学证据和知识产权 权威的专利 人体实验可获得 可获得产品与样品
18、For Internal Use Only19ImmunityImmunity为什么选择ampli-DWhy MRS 1515篇科学临床文献证实有效骨化二醇的黄金标准临床证明其生物利用度是原来的三倍下一代免疫健康的解决方案For Internal Use Only成功上市案例-汤臣倍健海外版ampli-D多维泡腾粉产品名称:汤臣倍健海外版ampliD 多维泡腾粉规格:3g/袋*25袋/盒产品成分及含量:500mg 维生素C,10ug ampliD,11mg 维生素B1,5.5mg维生素B2,22mg维生素B5,7mg 维生素B6,9ug维生素B12,15mg 锌零售价格:¥229For Int
19、ernal Use Only21For Internal Use Only22For Internal Use Only我们的核心原料也可以通过跨境CBEC的形式带给中国的消费者23For Internal Use Only24For Internal Use Only胆碱+11种维生素+锌+硒+锰非常好的解决了胆碱和其它B族维生素的苦味问题产品符合备案制凝胶软糖的法规要求,可申请备案制产品For Internal Use Only配方中使用了天然果胶,是“水果中的软黄金”,是一种维护肠道健康的水溶性膳食纤维产品符合备案制凝胶软糖的法规要求,可申请备案制产品For Internal Use Only27We bring progress to life