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1、Evaluation of a UV-C LED device for disinfection of medical instrumentsHannah SiweLaboratory of Liver Infectious Diseases,Faculty of Medicine and Health Sciences,Ghent University,Ghent,BelgiumResearch and Development,ZAPARAY,Lokeren,Belgium1OVERVIEWINTRODUCTION Ultraviolet radiation(UVR)and backgrou
2、nd UVR sources/UVR damage Hospital acquired infection(HAI)and infection prevention and control measures Reprocessing and challengesOBJECTIVESMETHODS Instrument assessment Workflow UV testingRESULTS Results on the standard surface(petri dish)and medical devices CONCLUSION23INTRODUCTIONSource:adapted
3、from Norcast weatherULTRAVIOLET RADIATION(UVR)ENERGY400Source:adapted from Browne,K.,Brought to Light:How Ultraviolet Disinfection Can Prevent the Nosocomial Transmission of COVID-19 and Other Infectious DiseasesINTRODUCTION%absorbedUV-CUV-BUV-A510095UV-CUV-BUV-AVacuumUVINITIAL UV DISCOVE
4、RYDISCOVERY OF MUTAGENIC PROPERTIES OF UVUSE OF UV FOR TREATMENT OF TB*Thomas BluntArthur Downes18771801Niels FinsenJohann Ritter1895*tuberculosis4BACKGROUND5UVR DAMAGELIPIDSPROTEINSDNARNAAgingSunburnSkin cancerCataractConjunctivitisBlindnessCELULLAR LEVELFigure made in BioRenderMACROSCOPIC LEVELUVR
5、 SOURCESTRADITIONAL UV MERCURY LAMPSLIGHT EMITTING DIODESEXCIMER LAMPSHeat generationmercurywavelength controllcompactlimited output intensitywavelength controllbroad spectrumlcostRelatively new technologydifferent sizesdifferent sizesozone7HOSPITAL ACQUIRED INFECTION(HAI)AND INFECTION PREVENTION AN
6、D CONTROL MEASURESSource:adapted from European Centre for Disease Prevention and Control(2016/2017)INFECTION PREVENTIONAND CONTROL MEASURES 4.9 log10 CFU/mLCOMPLETE REDUCTION 6.8 log10 CFU/mLPARTIAL REDUCTION 2 log10 CFU/mL(HINGE)NO REDUCTION(HOLLOW CAVITIES)COMPLETE REDUCTION 9 log10 CFU/mLSTANDARD
7、 SURFACECONCLUSION A variety of medical instruments were identified that could benefit from an alternativedisinfection solution.We obtained complete inactivation of a9 log10CFU/mL droplet of S.aureus ATCC 25923in a petri dish which demonstrates the high disinfecting ability of the UVC-LED device ona
8、 standard surface(smooth,flat,regular,non porous).We obtained complete,partial or no reduction depending on the instrument showing thatshape influences the disinfection efficiency.Disinfection efficiency on a standard surface is not a direct indicator for thedisinfection performance of a contaminate
9、d instrument with irregularities such ascavities,notches,and crevices.Shape combined with the desired level of disinfection of the instrument(Spaulding),should be considered when using a UVC device as an alternative disinfectiontechnology.22THANK YOULaboratory Bacteriology ResearchPiet CoolsLeen Van
10、 SimaeyAliona RoscaEline MeyersNick VersmessenLisa HimschootBodine Van Eenooghe23Laboratory of Liver Infectious DiseasesPhilip MeulemanLaura Corneillie Amse De MeyerFreya Van Houtte Lieven VerhoyeSilke TernestGhent University HospitalIsabel Leroux-RoelsAnnelies AerssensKrist HenrotinZAPARAYDuncan Ve
11、rstraetenNabi DastaranMieke FlourXavier DeklerckInstitute of Biomedical Engineering and TechnologyAlain KalmarCorrect implementation of current protocolImpact on lifespan of current protocolProcessing time of current protocolUse frequencyCost of instrumentHAI risk(patient+materialclassification)High
12、always executed correctlyfrequent damage or high wear and tearvery high TAT(Turn AroundTime)due to transfer to central sterilisation departmentmore then 10 x a daymore than 500 semi-critical material or othermaterial in severelyimmunocompromised patientsMidoccasionally wrongrisk of damagesmultiple s
13、teps with induction period,but locally executed(e.g.Tristell or clinell)more dan 1x per daybetween 50 and 500 semi-critical materialLowalmost never executed correctlyno or little impact on lifespanrapid cleaning and disinfection(e.g.Clinell)1x a day or less less than 50 non-critical instrumentsParameters and definitionsInstrument identification and assessment